Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds

A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, activ...

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 22; no. 1; pp. 28 - 32
Main Authors Zee-Cheng, Robert K. Y, Cheng, C. C
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.01.1979
Subjects
Animals
Antineoplastic Agents - chemical synthesis
Leukemia, Experimental - drug therapy
Mice
Structure-Activity Relationship
Thiadiazoles - chemical synthesis
Thiadiazoles - pharmacology
Thiazoles - chemical synthesis
Thiazoles - pharmacology
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - pharmacology
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Summary:A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an "isothioureido" [N-C(S-)=N-] or an "isothiosemicarbazono" [N-C(S-)=N-N=] structural unit.
Bibliography:ark:/67375/TPS-WGXZHCHN-G
istex:0496D6DC616D5FDDEF60263A3FAA13CCECC15658
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00187a007