Intermodular Communication in Polyketide Synthases: Comparing the Role of Protein−Protein Interactions to Those in Other Multidomain Proteins
Although the role of protein−protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are t...
Saved in:
| Published in | Biochemistry (Easton) Vol. 40; no. 8; pp. 2317 - 2325 |
|---|---|
| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
27.02.2001
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Although the role of protein−protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of modular megasynthases that channel covalently bound intermediates from one active site to the next. Recent biochemical studies have highlighted the importance of protein−protein interactions in these chain transfer processes. The information available on this subject is reviewed, and its possible mechanistic implications are placed in context by comparisons with selected well-studied multicomponent protein systems. |
|---|---|
| AbstractList | Although the role of protein-protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of modular megasynthases that channel covalently bound intermediates from one active site to the next. Recent biochemical studies have highlighted the importance of protein-protein interactions in these chain transfer processes. The information available on this subject is reviewed, and its possible mechanistic implications are placed in context by comparisons with selected well-studied multicomponent protein systems.Although the role of protein-protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of modular megasynthases that channel covalently bound intermediates from one active site to the next. Recent biochemical studies have highlighted the importance of protein-protein interactions in these chain transfer processes. The information available on this subject is reviewed, and its possible mechanistic implications are placed in context by comparisons with selected well-studied multicomponent protein systems. Although the role of protein−protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of modular megasynthases that channel covalently bound intermediates from one active site to the next. Recent biochemical studies have highlighted the importance of protein−protein interactions in these chain transfer processes. The information available on this subject is reviewed, and its possible mechanistic implications are placed in context by comparisons with selected well-studied multicomponent protein systems. Although the role of protein-protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the channeling of intermediates in metabolism is not widely appreciated. Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are two related families of modular megasynthases that channel covalently bound intermediates from one active site to the next. Recent biochemical studies have highlighted the importance of protein-protein interactions in these chain transfer processes. The information available on this subject is reviewed, and its possible mechanistic implications are placed in context by comparisons with selected well-studied multicomponent protein systems. |
| Author | Wu, Nicholas Tsuji, Stuart Y Khosla, Chaitan |
| Author_xml | – sequence: 1 givenname: Stuart Y surname: Tsuji fullname: Tsuji, Stuart Y – sequence: 2 givenname: Nicholas surname: Wu fullname: Wu, Nicholas – sequence: 3 givenname: Chaitan surname: Khosla fullname: Khosla, Chaitan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11327851$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkcFu1DAURS1URKeFBT-AvAGJRajtxHHCrkwLVLTqiA5sLcd5Ydwm9mA7FbNjCdt-Yr-EpBmKhLqyLZ17rHffHtqxzgJCzyl5QwmjB5UhhGU5u36EZpQzkmRlyXfQjBCSJ6zMyS7aC-FyeGZEZE_QLqUpEwWnM3RzYiP4ztV9qzyeu67rrdEqGmexsXjh2s0VRFMDvtjYuFIBwtvbn79Hcq28sd9wXAH-7FrArsEL7yIYe_vrZnvDd3qlR1_A0eHlygUYzedDzuOzvh3krlPjX1MkPEWPG9UGeLY999GX98fL-cfk9PzDyfzwNFEsz2JCywyEUsPkoqpVVRdUAE-zJqt4k9IcKtFw0egSlBZZMTCprnLGtagaQTij6T56NXnX3n3vIUTZmaChbZUF1wcpSMF4WYzgiy3YVx3Ucu1Np_xG_m1xAF5PgPYuBA_NP4TIcUPyfkMDe_Afq0286zt6ZdoHE8mUMCHCj3u18lcyF6ngcrm4kO-Ovn5aHJ2lkg_8y4lXOshL13s7tPiA9w8SO7LD |
| CitedBy_id | crossref_primary_10_1073_pnas_0601038103 crossref_primary_10_1016_j_chembiol_2006_06_011 crossref_primary_10_1038_nrg1084 crossref_primary_10_1021_acschembio_8b01060 crossref_primary_10_1080_713609311 crossref_primary_10_1074_jbc_M209719200 crossref_primary_10_1016_j_biomaterials_2003_08_041 crossref_primary_10_1073_pnas_2204075121 crossref_primary_10_1021_cr0301189 crossref_primary_10_1016_j_ddtec_2010_10_002 crossref_primary_10_7124_bc_00070E crossref_primary_10_1016_j_jbiotec_2019_08_008 crossref_primary_10_1016_S1367_5931_02_00360_5 crossref_primary_10_1039_B301028G crossref_primary_10_1073_pnas_0308082100 crossref_primary_10_1039_b815347g crossref_primary_10_1038_nrmicro1287 crossref_primary_10_1016_j_bmcl_2008_01_073 crossref_primary_10_7124_bc_000629 crossref_primary_10_1007_s00449_005_0001_8 crossref_primary_10_1016_j_jmb_2014_03_015 crossref_primary_10_1074_jbc_M111975200 crossref_primary_10_1016_j_chembiol_2005_12_012 crossref_primary_10_1562_0031_8655_2003_0770129PLOTNM2_0_CO2 crossref_primary_10_1039_b903087e crossref_primary_10_1110_ps_073011407 crossref_primary_10_1016_j_cbpa_2012_01_018 crossref_primary_10_1562_0031_8655_2003_077_0129_PLOTNM_2_0_CO_2 crossref_primary_10_1002_aic_690490402 crossref_primary_10_1007_s00284_005_0050_x crossref_primary_10_1073_pnas_0601924103 |
| Cites_doi | 10.1016/S0021-9258(19)81100-6 10.1111/j.1432-1033.1997.0260a.x 10.1146/annurev.biophys.26.1.259 10.1021/bi00422a025 10.1016/S0021-9258(18)67069-3 10.1021/ar50074a003 10.1016/S0167-4838(98)00079-X 10.1021/cr9600316 10.1128/jb.176.19.6127-6130.1994 10.1016/S0021-9258(17)44201-3 |
| ContentType | Journal Article |
| Copyright | Copyright © 2001 American Chemical Society |
| Copyright_xml | – notice: Copyright © 2001 American Chemical Society |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1021/bi002462v |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1520-4995 |
| EndPage | 2325 |
| ExternalDocumentID | 11327851 10_1021_bi002462v ark_67375_TPS_BDVKPDM3_5 b041121047 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, U.S. Gov't, P.H.S Comparative Study Review Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: 1 R01-CA66736 |
| GroupedDBID | - .K2 02 08R 186 23N 3O- 4.4 53G 55 55A 5GY 5RE 5VS 7~N 85S AABXI AAYJJ ABFLS ABMVS ABOCM ABPTK ABUCX ABUFD ACGFS ACJ ACNCT ACS ADKFC AEESW AENEX AETEA AFEFF AFFDN AFFNX AFMIJ AIDAL AJYGW ALMA_UNASSIGNED_HOLDINGS ANTXH AQSVZ BAANH CS3 D0L DU5 DZ EBS ED ED~ EJD F5P G8K GJ GNL IH9 IHE JG JG~ K2 K78 KM L7B LG6 MVM NHB OHT P2P ROL TN5 UI2 UNC UQL VF5 VG9 VQA W1F WH7 X X7M YZZ ZA5 ZE2 ZGI ZXP --- -DZ -~X .55 .GJ 6TJ ABDPE ABJNI ABQRX ADHLV AGXLV AHGAQ BSCLL CUPRZ GGK XOL XSW YYP ZCA ~02 ~KM AAYXX ABBLG ABLBI ACRPL ADNMO AEYZD AGQPQ ANPPW CITATION CGR CUY CVF ECM EIF NPM VXZ 7X8 |
| ID | FETCH-LOGICAL-a264t-194e7aa0027bdabd817e534f4b5f316eb7f57fc9eac7487bd3cb625c7bf705213 |
| IEDL.DBID | ACS |
| ISSN | 0006-2960 |
| IngestDate | Fri Jul 11 09:50:44 EDT 2025 Wed Feb 19 02:36:14 EST 2025 Tue Jul 01 01:55:04 EDT 2025 Thu Apr 24 23:08:29 EDT 2025 Wed Oct 30 10:00:17 EDT 2024 Thu Aug 27 13:41:58 EDT 2020 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-a264t-194e7aa0027bdabd817e534f4b5f316eb7f57fc9eac7487bd3cb625c7bf705213 |
| Notes | Research in the authors' laboratory on modular PKSs has been supported by grants from the National Institutes of Health (1 R01-CA66736), the National Science Foundation (BES 9806774), and the Strategic Research Fund of AstraZeneca, Inc. S.Y.T. is a recipient of an NSF Predoctoral Fellowship, and N.W. is a recipient of a Stanford−NIH Predoctoral Training Fellowship. istex:AAF3D6016E3C7D9AA5F5EA7C936DF7C2B9065CD6 ark:/67375/TPS-BDVKPDM3-5 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 |
| PMID | 11327851 |
| PQID | 70825981 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_70825981 pubmed_primary_11327851 crossref_primary_10_1021_bi002462v crossref_citationtrail_10_1021_bi002462v istex_primary_ark_67375_TPS_BDVKPDM3_5 acs_journals_10_1021_bi002462v |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 7~N ACJ VG9 W1F ANTXH ACS AEESW AFEFF .K2 ABMVS ABUCX IH9 BAANH AQSVZ ED~ UI2 CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2001-02-27 |
| PublicationDateYYYYMMDD | 2001-02-27 |
| PublicationDate_xml | – month: 02 year: 2001 text: 2001-02-27 day: 27 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Biochemistry (Easton) |
| PublicationTitleAlternate | Biochemistry |
| PublicationYear | 2001 |
| Publisher | American Chemical Society |
| Publisher_xml | – name: American Chemical Society |
| References | Wu N. (bi002462vb00044/bi002462vb00044_1) 2000; 122 Cane D. E. (bi002462vb00032/bi002462vb00032_1) 1999 Allen A. G. (bi002462vb00026/bi002462vb00026_1) 1989; 208 Banerjee R. V. (bi002462vb00008/bi002462vb00008_1) 1990 Hackert M. L. (bi002462vb00022/bi002462vb00022_1) 1983 Gokhale R. S. (bi002462vb00048/bi002462vb00048_1) 1998 Drummond J. T. (bi002462vb00011/bi002462vb00011_1) 1993 de Kok A. (bi002462vb00017/bi002462vb00017_1) 1998; 1385 Cortes J. (bi002462vb00041/bi002462vb00041_1) 1990 Bates D. L. (bi002462vb00027/bi002462vb00027_1) 1977 Carreras C. W. (bi002462vb00030/bi002462vb00030_1) 1997; 188 Stoops J. K. (bi002462vb00035/bi002462vb00035_1) 1983; 258 Jarrett J. T. (bi002462vb00016/bi002462vb00016_1) 1998 Goulding C. W. (bi002462vb00014/bi002462vb00014_1) 1996; 10 Banerjee R. V. (bi002462vb00012/bi002462vb00012_1) 1989; 264 Wilkinson B. (bi002462vb00051/bi002462vb00051_1) 2000 Yuan Z. Y. (bi002462vb00039/bi002462vb00039_1) 1986; 261 Mootz H. D. (bi002462vb00049/bi002462vb00049_1) 2000 Foster R. J. (bi002462vb00038/bi002462vb00038_1) 1985; 260 Stoops J. K. (bi002462vb00037/bi002462vb00037_1) 1981; 256 Tsuji S. Y. (bi002462vb00045/bi002462vb00045_1) 2001 Stoops J. K. (bi002462vb00034/bi002462vb00034_1) 1982; 257 Joshi A. K. (bi002462vb00033/bi002462vb00033_1) 1998 O'Shea E. K. (bi002462vb00002/bi002462vb00002_1) 1989 Reed L. J. (bi002462vb00021/bi002462vb00021_1) 1974; 7 O'Shea E. K. (bi002462vb00003/bi002462vb00003_1) 1989 Kuriyan J. (bi002462vb00005/bi002462vb00005_1) 1997; 26 Gokhale R. S. (bi002462vb00043/bi002462vb00043_1) 1999 Gonfloni S. (bi002462vb00007/bi002462vb00007_1) 1999 Dafydd Jones D. (bi002462vb00023/bi002462vb00023_1) 2000 Roberts D. L. (bi002462vb00015/bi002462vb00015_1) 1994; 176 Chirala S. S. (bi002462vb00052/bi002462vb00052_1) 2001 Staunton J. (bi002462vb00031/bi002462vb00031_1) 1997; 97 bi002462vb00009/bi002462vb00009_1 Hengeveld A. F. (bi002462vb00020/bi002462vb00020_1) 1997; 250 Banerjee R. V. (bi002462vb00010/bi002462vb00010_1) 1990 Drummond J. T. (bi002462vb00013/bi002462vb00013_1) 1993 Kao C. M. (bi002462vb00047/bi002462vb00047_1) 1996 Chang S. I. (bi002462vb00040/bi002462vb00040_1) 1989 Dave E. (bi002462vb00024/bi002462vb00024_1) 1995 Cohen G. B. (bi002462vb00004/bi002462vb00004_1) 1995 Collins J. H. (bi002462vb00028/bi002462vb00028_1) 1977 Perham R. N. (bi002462vb00018/bi002462vb00018_1) 1991 Stoops J. K. (bi002462vb00036/bi002462vb00036_1) 1980 Smith S. (bi002462vb00029/bi002462vb00029_1) 1994; 8 Williams J. C. (bi002462vb00006/bi002462vb00006_1) 1998 Staunton J. (bi002462vb00046/bi002462vb00046_1) 1996 Belshaw P. J. (bi002462vb00050/bi002462vb00050_1) 1999 Angel P. (bi002462vb00001/bi002462vb00001_1) 1991; 1072 Guest J. R. (bi002462vb00025/bi002462vb00025_1) 1997 Reed L. J. (bi002462vb00019/bi002462vb00019_1) 1990; 265 |
| References_xml | – volume-title: Trends Biochem. Sci. 23, 179−184 year: 1998 ident: bi002462vb00006/bi002462vb00006_1 – volume-title: Biochemistry 32, 9290−9295 year: 1993 ident: bi002462vb00011/bi002462vb00011_1 – volume: 257 start-page: 3230 year: 1982 ident: bi002462vb00034/bi002462vb00034_1 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(19)81100-6 – volume-title: Microbiology 143, 457−466 year: 1997 ident: bi002462vb00025/bi002462vb00025_1 – volume-title: Biochemistry 28, 3781−3788 year: 1989 ident: bi002462vb00040/bi002462vb00040_1 – volume: 1072 year: 1991 ident: bi002462vb00001/bi002462vb00001_1 publication-title: Biochim. Biophys. Acta – volume: 250 year: 1997 ident: bi002462vb00020/bi002462vb00020_1 publication-title: Eur. J. Biochem. doi: 10.1111/j.1432-1033.1997.0260a.x – volume: 26 year: 1997 ident: bi002462vb00005/bi002462vb00005_1 publication-title: Annu. Rev. Biophys. Biomol. Struct. doi: 10.1146/annurev.biophys.26.1.259 – volume-title: Proc. Natl. Acad. Sci. U.S.A. 74, 4223−4227 year: 1977 ident: bi002462vb00028/bi002462vb00028_1 – volume-title: Chem. Biol. 7, 111−117 year: 2000 ident: bi002462vb00051/bi002462vb00051_1 – volume-title: Biochemistry 37, 2515−2523 year: 1998 ident: bi002462vb00033/bi002462vb00033_1 – volume: 8 year: 1994 ident: bi002462vb00029/bi002462vb00029_1 publication-title: FASEB J. – volume-title: Biochemistry 29, 1129−1135 year: 1990 ident: bi002462vb00010/bi002462vb00010_1 – volume-title: Biochemistry 37, 5372−5382 year: 1998 ident: bi002462vb00016/bi002462vb00016_1 – ident: bi002462vb00009/bi002462vb00009_1 doi: 10.1021/bi00422a025 – volume-title: Cell 80, 237−248 year: 1995 ident: bi002462vb00004/bi002462vb00004_1 – volume: 261 start-page: 13643 year: 1986 ident: bi002462vb00039/bi002462vb00039_1 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)67069-3 – volume-title: R319−R325. year: 1999 ident: bi002462vb00032/bi002462vb00032_1 – volume-title: Biochemistry 29, 11101−11109 year: 1990 ident: bi002462vb00008/bi002462vb00008_1 – volume-title: Nat. Struct. Biol. 3, 188−192 year: 1996 ident: bi002462vb00046/bi002462vb00046_1 – volume-title: Science 284, 486−489 year: 1999 ident: bi002462vb00050/bi002462vb00050_1 – volume: 256 year: 1981 ident: bi002462vb00037/bi002462vb00037_1 publication-title: J. Biol. Chem. – volume-title: Nature 268, 313−316 year: 1977 ident: bi002462vb00027/bi002462vb00027_1 – volume-title: Proc. Natl. Acad. Sci. U.S.A. 80, 2907−2911 year: 1983 ident: bi002462vb00022/bi002462vb00022_1 – volume: 7 start-page: 46 year: 1974 ident: bi002462vb00021/bi002462vb00021_1 publication-title: Acc. Chem. Res. doi: 10.1021/ar50074a003 – volume: 1385 year: 1998 ident: bi002462vb00017/bi002462vb00017_1 publication-title: Biochim. Biophys. Acta doi: 10.1016/S0167-4838(98)00079-X – volume: 208 year: 1989 ident: bi002462vb00026/bi002462vb00026_1 publication-title: J. Mol. Biol. – volume: 122 year: 2000 ident: bi002462vb00044/bi002462vb00044_1 publication-title: J. Am. Chem. Soc. – volume: 265 year: 1990 ident: bi002462vb00019/bi002462vb00019_1 publication-title: J. Biol. Chem. – volume-title: Proc. Natl. Acad. Sci. U.S.A. 77, 4544−4548 year: 1980 ident: bi002462vb00036/bi002462vb00036_1 – volume: 97 year: 1997 ident: bi002462vb00031/bi002462vb00031_1 publication-title: Chem. Rev. doi: 10.1021/cr9600316 – volume-title: Biochemistry 37, 2524−2528 year: 1998 ident: bi002462vb00048/bi002462vb00048_1 – volume: 264 year: 1989 ident: bi002462vb00012/bi002462vb00012_1 publication-title: J. Biol. Chem. – volume-title: Biochemistry 39, 8448−8459 year: 2000 ident: bi002462vb00023/bi002462vb00023_1 – volume-title: Science 243, 538−542 year: 1989 ident: bi002462vb00002/bi002462vb00002_1 – volume-title: Science 245, 646−648 year: 1989 ident: bi002462vb00003/bi002462vb00003_1 – volume-title: Proc. Natl. Acad. Sci. U.S.A. 97, 5848−5853 year: 2000 ident: bi002462vb00049/bi002462vb00049_1 – volume-title: Science 284, 482−485 year: 1999 ident: bi002462vb00043/bi002462vb00043_1 – volume-title: Biochemistry 30, 8501−8512 year: 1991 ident: bi002462vb00018/bi002462vb00018_1 – volume-title: Biochemistry 40, 2326−2331 year: 2001 ident: bi002462vb00045/bi002462vb00045_1 – volume: 260 year: 1985 ident: bi002462vb00038/bi002462vb00038_1 publication-title: J. Biol. Chem. – volume-title: Nat. Struct. Biol. 6, 760−764 year: 1999 ident: bi002462vb00007/bi002462vb00007_1 – volume-title: Biochemistry 35, 12363−12368 year: 1996 ident: bi002462vb00047/bi002462vb00047_1 – volume-title: Biochemistry 32, 9282−9289 year: 1993 ident: bi002462vb00013/bi002462vb00013_1 – volume-title: Microbiology 141 year: 1995 ident: bi002462vb00024/bi002462vb00024_1 – volume: 10 year: 1996 ident: bi002462vb00014/bi002462vb00014_1 publication-title: FASEB J. – volume-title: Proc. Natl. Acad. Sci. U.S.A. (in press) year: 2001 ident: bi002462vb00052/bi002462vb00052_1 – volume: 176 year: 1994 ident: bi002462vb00015/bi002462vb00015_1 publication-title: J. Bacteriol. doi: 10.1128/jb.176.19.6127-6130.1994 – volume: 258 year: 1983 ident: bi002462vb00035/bi002462vb00035_1 publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)44201-3 – volume-title: Nature 348, 176−178 year: 1990 ident: bi002462vb00041/bi002462vb00041_1 – volume: 188 start-page: 126 year: 1997 ident: bi002462vb00030/bi002462vb00030_1 publication-title: Top. Curr. Chem. |
| SSID | ssj0004074 |
| Score | 1.8336093 |
| SecondaryResourceType | review_article |
| Snippet | Although the role of protein−protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the... Although the role of protein-protein interactions in transducing signals within biological systems has been extensively explored, their relevance to the... |
| SourceID | proquest pubmed crossref istex acs |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 2317 |
| SubjectTerms | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - chemistry 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism Animals Humans Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Protein Structure, Tertiary Proteins - chemistry Proteins - metabolism Proto-Oncogene Proteins c-fos - chemistry Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - chemistry Proto-Oncogene Proteins c-jun - metabolism Pyruvate Dehydrogenase Complex - chemistry Pyruvate Dehydrogenase Complex - metabolism src-Family Kinases - chemistry src-Family Kinases - metabolism |
| Title | Intermodular Communication in Polyketide Synthases: Comparing the Role of Protein−Protein Interactions to Those in Other Multidomain Proteins |
| URI | http://dx.doi.org/10.1021/bi002462v https://api.istex.fr/ark:/67375/TPS-BDVKPDM3-5/fulltext.pdf https://www.ncbi.nlm.nih.gov/pubmed/11327851 https://www.proquest.com/docview/70825981 |
| Volume | 40 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1LU9RAEO5COOgFFVRWBafUorwEzeQxu95wV4rSQrfcxeKWmsnMyBa7iUWyFOvJo1z5ifwSuyfJIiXoLYd5JNM96a9n-usGeBlZGxvtWw9tfeSFKHRP8lR4PIy14IGWbVdFYe9TvLsffjiIDhbgxQ03-Nx_rUZkR2J-cguWeIybl_BPd3BJfnxTp1pG15gjHm_SB_3ZlUxPWlwxPUu0iqc340pnX3buQq9h6VRhJUdb01JtpT_-Ttr4r1e_B8s1vmTblULchwWTrcDqdoa-9WTGNpmL-HRH6Stwu9tUe1uFc3c0OMk1haWyK7QRNspYPx_PiB2tDRvMsvIQbV_x9uLnGetWdQyzbwyRJPuSjw3LLetT9odRdvHrvH5ibviKRFGwMmfDw7wwNPJnQqDM8YB1PpE0V9WleAD7O--H3V2vrteA4o3D0vM7oRFSkqertFS67QsTBaENVWQDPzZK2EjYtIP_eoF-ktJBqtD9SoWygjjEwUNYzPLMrAFDYdqgE2qVIsSg0iBRKNGTV0RnESmPW7CBAk3q_VYk7iqd-8l8xVvwqpF1ktbZzqnoxvi6ps_nTb9XKT6ua7TpFGbeQh4fUUyciJJhf5C863392O_tBUnUgmeNRiUoQrp-kZnJp0UiyBvvtP0WPKoU7XI2P-ACoe_j_33VE7hTxcARpeopLJbHU7OOoKhUG25T_Aa8Ewg8 |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lc9MwENZAeygXHi2P8Gg1DNPh4oJt2Uq4hZROoE3JkJTpTWNZEs00sZjKYQgnjnDtT-wvYVd2EsqUgZsPeu_a-6213y4hzxJjUq1CE4CtTwIGQg-yKOdBxFLFo1hlTV9FoXeYdo_Yu-PkuE6Tg1wYWISDkZy_xF9mFwhfyBGakzT6cp2sAgiJUJvbncGSA_myzrgMHnIEsHyeRej3rmiBcnfJAq3iYX79O7z0ZmbvVlWvyC_QR5ec7kxLuZN_-yN34__t4Da5WaNN2q7U4w65pot1stEuwNOezOg29fGf_sf6OlnrzGu_bZBz_6NwYhUGqdJLJBI6KmjfjmfIlVaaDmZFeQKW0L26-P6TdqqqhsUnCriSfrBjTa2hfcwFMSoufpzXT9QPX1EqHC0tHZ5Yp3Hk94hHqWcFKzvJcK6qi7tLjvbeDDvdoK7eAMJOWRmELaZ5lqHfK1UmVTPkOomZYTIxcZhqyU3CTd6CLz8Hr0mqOJfgjOVcGo6M4vgeWSlsoR8QCjI1cYspmQPgwEIhCcvAr5dIbuF5lDbIJhy4qN8-J_zFehSKxYk3yPO5yEVe5z7HEhzjq5o-XTT9XCX8uKrRttebRYvs7BQj5Hgihv2BeL37cb-_24tF0iBbc8USIEK8jMkKbadOcPTNW82wQe5X-racLYwjDkD44b92tUXWusPegTh4e7j_iNyoouOQbPWYrJRnU_0E4FIpN_178guEpRCd |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9NAEB5BKwEXCi2P8GhXCFVcXPBzk95CQlQobS2SVr2tvN5dGjWxq9pBpKce4dqf2F_CzNpJKSqCmw_jfc2sZmZnvhmA16ExkVaucVDXh06ATHcSL-WOF0SKe75KmraLws5utLUffDoMD2tHkbAwuIgCRypsEJ9u9YkydYUB960ckkqJvG-3YZHCdSTR7U7_Cgf5rq66jF6yh6b5rJLQ77-SFkqLa1pokQ70-99NTKtqekuwN1-kzTA53piUciM9-6N-4__v4gHcr61O1q7E5CHc0tkyrLQz9LjHU7bObB6ofWBfhrudWQ-4FbiwD4bjXFGyKrsGJmHDjMX5aEqYaaVZf5qVR6gRi83L85-sU3U3zL4ytC_Zl3ykWW5YTDUhhtnlj4v6i9nhK2hFwcqcDY7yQtPIe2SXMosOVvk4obmqX4pHsN_7MOhsOXUXB2R6FJSO2wo0TxLyf6VKpGq6XId-YAIZGt-NtOQm5CZtoQbg6D1J5acSnbKUS8MJWew_hoUsz_RTYMhX47cCJVM0PKhhSBgk6N9LArnw1IsasIqHLupbWAgbYPdcMT_xBryZsV2kdQ10asUxuon01Zz0pCr8cRPRupWdOUVyekyZcjwUg7gv3ncPtuPuji_CBqzNhEsgCykok2Q6nxSCk4_earoNeFLJ3NVsru9xNIif_WtXa3An7vbE54-728_hXpUkR5irF7BQnk70S7SaSrlqr8ovQM8TIA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Intermodular+communication+in+polyketide+synthases%3A+comparing+the+role+of+protein-protein+interactions+to+those+in+other+multidomain+proteins&rft.jtitle=Biochemistry+%28Easton%29&rft.au=Tsuji%2C+S+Y&rft.au=Wu%2C+N&rft.au=Khosla%2C+C&rft.date=2001-02-27&rft.issn=0006-2960&rft.volume=40&rft.issue=8&rft.spage=2317&rft_id=info:doi/10.1021%2Fbi002462v&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-2960&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-2960&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-2960&client=summon |