Synthesis of 1-Amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic Acid:  A Potential BNCT Agent

• Published in: Journal of organic chemistry Vol. 62; no. 13; pp. 4476 - 4478
• Main Authors: Srivastava, Rajiv R, Singhaus, Robert R, Kabalka, George W
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.06.1997

The synthesis of an unnatural amino acid, 1-amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic acid, was achieved. This new potential BNCT agent was prepared via the monoalkylation of m-carborane with 4-bromobutene to produce 4-m-carboranyl-1-butene, which was then subjec...