Development of a Fit-for-Purpose Large-Scale Synthesis of an Oral PARP Inhibitor

• Published in: Organic process research & development Vol. 15; no. 4; pp. 831 - 840
• Main Authors: Wallace, Debra J, Baxter, Carl A, Brands, Karel J. M, Bremeyer, Nadine, Brewer, Sarah E, Desmond, Richard, Emerson, Khateeta M, Foley, Jennifer, Fernandez, Paul, Hu, Weifeng, Keen, Stephen P, Mullens, Peter, Muzzio, Daniel, Sajonz, Peter, Tan, Lushi, Wilson, Robert D, Zhou, George, Zhou, Guoyue
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.07.2011

Compound (1) a poly(ADP-ribose)polymerase (PARP) inhibitor has been made by a fit-for-purpose large-scale synthesis using either a classical resolution or chiral chromatographic separation. The development and relative merits of each route are discussed, along with operational improvements and exten...