Large-Scale Continuous Flow Transformation of Oximes into Fused-Bicyclic Isoxazolidines: An Example of Process Intensification

• Published in: Organic process research & development Vol. 19; no. 2; pp. 347 - 351
• Main Authors: Rincón, Juan A, Mateos, Carlos, García-Losada, Pablo, Mergott, Dustin J
• Format: Journal Article
• Language: English
• Published: American Chemical Society 20.02.2015

Here, we report a continuous flow protocol for the [3 + 2] cycloaddition of nitrones, in situ generated from oximes, into bicyclic isoxazolidines. This thermal process required very high temperatures to be efficient that were not easily reached in conventional reactors. A couple of examples are pres...