Carbosulfonylation of Alkynes: A Direct Conversion of sp‑C to sp3‑C through Visible Light-Mediated 3‑Component Reaction
A 3-component metal-free carbosulfonylation of alkynes is reported using readily available alkyl carboxylic acids and arylsulfinates under visible light irradiation. This photochemical approach gives direct conversion of sp-C to sp3-C yielding highly functionalized alkyl sulfones. It employs feedst...
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Published in | Organic letters Vol. 26; no. 37; pp. 7858 - 7863 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
American Chemical Society
20.09.2024
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Subjects | |
Online Access | Get full text |
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Summary: | A 3-component metal-free carbosulfonylation of alkynes is reported using readily available alkyl carboxylic acids and arylsulfinates under visible light irradiation. This photochemical approach gives direct conversion of sp-C to sp3-C yielding highly functionalized alkyl sulfones. It employs feedstock chemicals as starting materials and shows a broad substrate scope and moderate diastereoselectivity. The method’s utility is highlighted in the synthesis of sedum alkaloids. A single photocatalyst is proposed to be active in two distinct photocatalytic cycles operating in tandem. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1523-7060 1523-7052 1523-7052 |
DOI: | 10.1021/acs.orglett.4c02700 |