Efficient Purification of an Active Pharmaceutical Ingredient via Cocrystallization: From Thermodynamics to Scale-Up

Cocrystallization as a purification step was the only way to isolate an active pharmaceutical ingredient with acceptable chemical and physical specifications. The process design controlling chemical quality and polymorphism issues is described, from the thermodynamics of cocrystal formation and clea...

Full description

Saved in:
Bibliographic Details
Published inOrganic process research & development Vol. 17; no. 3; pp. 505 - 511
Main Authors Billot, Pascal, Hosek, Patrik, Perrin, Marc-Antoine
Format Journal Article
LanguageEnglish
Published American Chemical Society 15.03.2013
Online AccessGet full text

Cover

More Information
Summary:Cocrystallization as a purification step was the only way to isolate an active pharmaceutical ingredient with acceptable chemical and physical specifications. The process design controlling chemical quality and polymorphism issues is described, from the thermodynamics of cocrystal formation and cleavage, to microscale data acquisition, to laboratory scale-up and transfer to the pilot plant.
ISSN:1083-6160
1520-586X
DOI:10.1021/op300214p