Solubility and Solution Thermodynamics of Diphenoxylate in Different Pure Solvents

The solubility data of diphenoxylate in pure solvents of water, methanol, ethanol, acetone, acetonitrile, 2-propanol were measured within the temperature range of 293.15–318.15 K by a static analytical method under atmospheric pressure. Several commonly used thermodynamic models, including the ideal...

Full description

Saved in:
Bibliographic Details
Published inJournal of chemical and engineering data Vol. 60; no. 6; pp. 1629 - 1633
Main Authors Qing, Xue-Yan, Fu, Hua-Lin, Shu, Gang, Liu, Meng-Jiao, Zhou, Jian-Yu, Wu, Wen-Bin, Zhang, Yan-Li, Zhou, Jun-Jie
Format Journal Article
LanguageEnglish
Published American Chemical Society 11.06.2015
Online AccessGet full text

Cover

Abstract The solubility data of diphenoxylate in pure solvents of water, methanol, ethanol, acetone, acetonitrile, 2-propanol were measured within the temperature range of 293.15–318.15 K by a static analytical method under atmospheric pressure. Several commonly used thermodynamic models, including the ideal solution model, the modified Apelblat equation and the Buchowski-Ksiazaczak λh equation, were applied to correlate the experimental solubility data. The experimental results show that the solubility increases with the increasing temperature, and the highest solubility is in methanol, the lowest in pure water. Results of these measurements were well-correlated with the three equations above, but the modified Apelblat equation is more suitable in regressing the solubility data of diphenoxylate. Through the Van’t Hoff equation, the enthalpy and the entropy in different solvents can be calculated.
AbstractList The solubility data of diphenoxylate in pure solvents of water, methanol, ethanol, acetone, acetonitrile, 2-propanol were measured within the temperature range of 293.15–318.15 K by a static analytical method under atmospheric pressure. Several commonly used thermodynamic models, including the ideal solution model, the modified Apelblat equation and the Buchowski-Ksiazaczak λh equation, were applied to correlate the experimental solubility data. The experimental results show that the solubility increases with the increasing temperature, and the highest solubility is in methanol, the lowest in pure water. Results of these measurements were well-correlated with the three equations above, but the modified Apelblat equation is more suitable in regressing the solubility data of diphenoxylate. Through the Van’t Hoff equation, the enthalpy and the entropy in different solvents can be calculated.
Author Qing, Xue-Yan
Liu, Meng-Jiao
Zhou, Jun-Jie
Fu, Hua-Lin
Zhou, Jian-Yu
Wu, Wen-Bin
Shu, Gang
Zhang, Yan-Li
AuthorAffiliation Department of Pharmacy, College of Veterinary Medicine
Sichuan Agricultural University
AuthorAffiliation_xml – name: Department of Pharmacy, College of Veterinary Medicine
– name: Sichuan Agricultural University
Author_xml – sequence: 1
  givenname: Xue-Yan
  surname: Qing
  fullname: Qing, Xue-Yan
– sequence: 2
  givenname: Hua-Lin
  surname: Fu
  fullname: Fu, Hua-Lin
  email: fuhl2005@sohu.com
– sequence: 3
  givenname: Gang
  surname: Shu
  fullname: Shu, Gang
– sequence: 4
  givenname: Meng-Jiao
  surname: Liu
  fullname: Liu, Meng-Jiao
– sequence: 5
  givenname: Jian-Yu
  surname: Zhou
  fullname: Zhou, Jian-Yu
– sequence: 6
  givenname: Wen-Bin
  surname: Wu
  fullname: Wu, Wen-Bin
– sequence: 7
  givenname: Yan-Li
  surname: Zhang
  fullname: Zhang, Yan-Li
– sequence: 8
  givenname: Jun-Jie
  surname: Zhou
  fullname: Zhou, Jun-Jie
BookMark eNptkM1OwzAQhC1UJNLCgTfwhQOHwDq2k_iIyq9UCQTlHDnJWnWV2JWdIvL2pCrixGk1O9-uRjMnM-cdEnLJ4IZBxm63KIEBcH5CEiYzSCXjYkYSmMxUybw8I_MYtwAgiowl5P3Dd_vadnYYqXYtPcjBekfXGwy9b0ene9tE6g29t7sNOv89dnpAat20MAYDuoG-7QMeTr8mEc_JqdFdxIvfuSCfjw_r5XO6en16Wd6tUp1JNaSsxoZjoRiTaFQu2wbAFFqKKXWZZ0IjqkJwFIYbnYumlLXKyjbXXBmWq5ovyPXxbxN8jAFNtQu212GsGFSHMqq_Mib26sjqJlZbvw9uSvYP9wNprF-4
CitedBy_id crossref_primary_10_1021_acs_jced_0c00267
crossref_primary_10_1016_j_molliq_2021_116603
crossref_primary_10_1002_chem_201701011
crossref_primary_10_1590_s2175_97902023e20918
crossref_primary_10_1208_s12249_018_1244_4
crossref_primary_10_1016_j_jct_2022_106777
crossref_primary_10_1021_acs_jced_9b00411
Cites_doi 10.1016/j.molliq.2013.11.029
10.1016/S0065-2377(08)60082-4
10.1016/j.fluid.2014.03.022
10.1016/j.jemermed.2007.03.051
10.1016/j.fluid.2014.01.043
10.1016/j.fluid.2014.01.008
10.1016/S0928-0987(03)00145-3
10.1016/j.bmcl.2012.09.080
10.1016/0014-2999(75)90230-7
10.1016/j.jct.2010.09.013
10.1097/01.pra.0000281491.65311.c3
10.1016/j.ejpb.2003.10.021
10.1016/S0939-6411(00)00076-X
10.1071/CH9740477
10.1016/j.molliq.2013.07.014
10.1016/0378-3812(94)80058-8
ContentType Journal Article
Copyright Copyright © American Chemical Society
Copyright_xml – notice: Copyright © American Chemical Society
DBID AAYXX
CITATION
DOI 10.1021/je5010033
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Chemistry
EISSN 1520-5134
EndPage 1633
ExternalDocumentID 10_1021_je5010033
d014295084
GroupedDBID 02
08R
1WB
4.4
53G
55A
5GY
5VS
6XO
7~N
AABXI
ABFLS
ABMVS
ABPPZ
ABPTK
ABUCX
ACGFS
ACJ
ACS
AEESW
AENEX
AETEA
AFEFF
AFFNX
AGXLV
ALMA_UNASSIGNED_HOLDINGS
ANTXH
AQSVZ
CS3
DU5
DZ
EBS
ED
ED~
EJD
F5P
G8K
GNL
IH9
IHE
JG
JG~
LG6
MVM
P2P
RNS
ROL
UI2
VF5
VG9
VOH
W1F
WH7
X
YZZ
ZCG
ZY4
-DZ
-~X
.DC
AAHBH
AAYXX
ABHMW
ABJNI
ABQRX
ADHLV
AHGAQ
CITATION
CUPRZ
GGK
~02
ID FETCH-LOGICAL-a259t-1bec3e79115ef965dc00f7a545208624aee9743e4f3fa64c85b928d6a39f169b3
IEDL.DBID ACS
ISSN 0021-9568
IngestDate Fri Aug 23 01:24:52 EDT 2024
Thu Aug 27 13:42:41 EDT 2020
IsPeerReviewed true
IsScholarly true
Issue 6
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a259t-1bec3e79115ef965dc00f7a545208624aee9743e4f3fa64c85b928d6a39f169b3
PageCount 5
ParticipantIDs crossref_primary_10_1021_je5010033
acs_journals_10_1021_je5010033
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
ACJ
AGXLV
VG9
W1F
ANTXH
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
1WB
AQSVZ
ED~
UI2
PublicationCentury 2000
PublicationDate 2015-06-11
PublicationDateYYYYMMDD 2015-06-11
PublicationDate_xml – month: 06
  year: 2015
  text: 2015-06-11
  day: 11
PublicationDecade 2010
PublicationTitle Journal of chemical and engineering data
PublicationTitleAlternate J. Chem. Eng. Data
PublicationYear 2015
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References Nguyen W. (ref2/cit2) 2012; 22
Ksiazczak A. (ref12/cit12) 1994; 95
Dajani E. Z. (ref1/cit1) 1975; 34
Firoozabadi A. (ref3/cit3) 2007; 13
Perlovich G. L. (ref15/cit15) 2003; 19
Leuner C. (ref5/cit5) 2000; 50
Thomas T. J. (ref4/cit4) 2008; 34
Ouyang J. (ref11/cit11) 2014; 372
Cox B. G. (ref8/cit8) 1974; 27
Liu X. (ref7/cit7) 2014; 367
Zhi W. (ref14/cit14) 2013; 187
Ren Y. (ref10/cit10) 2014; 191
Prausnitz J. M. (ref9/cit9) 1968
Xiao M. (ref6/cit6) 2011; 43
Jiang L. (ref13/cit13) 2014; 367
Perlovich G. L. (ref16/cit16) 2004; 57
References_xml – volume: 191
  start-page: 53
  issue: 0
  year: 2014
  ident: ref10/cit10
  publication-title: J. Mol. Liq.
  doi: 10.1016/j.molliq.2013.11.029
  contributor:
    fullname: Ren Y.
– start-page: 139
  year: 1968
  ident: ref9/cit9
  publication-title: Adv. Chem. Eng.
  doi: 10.1016/S0065-2377(08)60082-4
  contributor:
    fullname: Prausnitz J. M.
– volume: 372
  start-page: 7
  year: 2014
  ident: ref11/cit11
  publication-title: Fluid Phase Equilib.
  doi: 10.1016/j.fluid.2014.03.022
  contributor:
    fullname: Ouyang J.
– volume: 34
  start-page: 71
  issue: 1
  year: 2008
  ident: ref4/cit4
  publication-title: J. Emerg. Med.
  doi: 10.1016/j.jemermed.2007.03.051
  contributor:
    fullname: Thomas T. J.
– volume: 367
  start-page: 117
  issue: 0
  year: 2014
  ident: ref13/cit13
  publication-title: Fluid Phase Equilib.
  doi: 10.1016/j.fluid.2014.01.043
  contributor:
    fullname: Jiang L.
– volume: 367
  start-page: 1
  issue: 0
  year: 2014
  ident: ref7/cit7
  publication-title: Fluid Phase Equilib.
  doi: 10.1016/j.fluid.2014.01.008
  contributor:
    fullname: Liu X.
– volume: 19
  start-page: 423
  issue: 5
  year: 2003
  ident: ref15/cit15
  publication-title: Eur. J. Pharm. Sci.
  doi: 10.1016/S0928-0987(03)00145-3
  contributor:
    fullname: Perlovich G. L.
– volume: 22
  start-page: 7106
  issue: 23
  year: 2012
  ident: ref2/cit2
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/j.bmcl.2012.09.080
  contributor:
    fullname: Nguyen W.
– volume: 34
  start-page: 105
  issue: 1
  year: 1975
  ident: ref1/cit1
  publication-title: Eur. J. Pharmacol.
  doi: 10.1016/0014-2999(75)90230-7
  contributor:
    fullname: Dajani E. Z.
– volume: 43
  start-page: 240
  issue: 3
  year: 2011
  ident: ref6/cit6
  publication-title: J. Chem. Thermodyn.
  doi: 10.1016/j.jct.2010.09.013
  contributor:
    fullname: Xiao M.
– volume: 13
  start-page: 278
  issue: 4
  year: 2007
  ident: ref3/cit3
  publication-title: J. Psychiatr. Pract.
  doi: 10.1097/01.pra.0000281491.65311.c3
  contributor:
    fullname: Firoozabadi A.
– volume: 57
  start-page: 411
  issue: 2
  year: 2004
  ident: ref16/cit16
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/j.ejpb.2003.10.021
  contributor:
    fullname: Perlovich G. L.
– volume: 50
  start-page: 47
  issue: 1
  year: 2000
  ident: ref5/cit5
  publication-title: Eur. J. Pharm. Biopharm.
  doi: 10.1016/S0939-6411(00)00076-X
  contributor:
    fullname: Leuner C.
– volume: 27
  start-page: 477
  issue: 3
  year: 1974
  ident: ref8/cit8
  publication-title: Aust. J. Chem.
  doi: 10.1071/CH9740477
  contributor:
    fullname: Cox B. G.
– volume: 187
  start-page: 201
  issue: 0
  year: 2013
  ident: ref14/cit14
  publication-title: J. Mol. Liq.
  doi: 10.1016/j.molliq.2013.07.014
  contributor:
    fullname: Zhi W.
– volume: 95
  start-page: 15
  issue: 0
  year: 1994
  ident: ref12/cit12
  publication-title: Fluid Phase Equilib.
  doi: 10.1016/0378-3812(94)80058-8
  contributor:
    fullname: Ksiazczak A.
SSID ssj0004721
Score 2.2111106
Snippet The solubility data of diphenoxylate in pure solvents of water, methanol, ethanol, acetone, acetonitrile, 2-propanol were measured within the temperature range...
SourceID crossref
acs
SourceType Aggregation Database
Publisher
StartPage 1629
Title Solubility and Solution Thermodynamics of Diphenoxylate in Different Pure Solvents
URI http://dx.doi.org/10.1021/je5010033
Volume 60
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1bS8MwFD7M-aA-eJmK8zKC-trZtEnaPsrmGIIi6mBvI2kTmJdO1u5Bf70n7YqFob6GpIScpOc7J1_OB3AZcSm4Up4Tu1w6LHQjPHOUO0bqMBZBYsIioX93L4Yjdjvm4wZc_HKD79GrF80xZnB9fw3WPcsctPin9_Tz-DHwSlk8yzXgIqzKB9WHWtcTZzXXU_Mhgx3oVy9xSurIa3eRq278tVqY8a_p7cL2EkOS69Loe9DQaQs2epV0Wwu2alUG9-HRpr4KDuwnkWlCqkwYwS0yf58lpSZ9RmaG9KeW8oWze0MISqYpNpT6KTl5WMy1HWr5kdkBjAY3z72hs5RScCTGN7lD0VS-DvDPxrWJBE9i1zWBtALjNqZhUmsMLHzNjG-kYHHIVeSFiZB-ZKiIlH8IzXSW6iMghlKjBNrTJBFThoXMY4gyrONHh6iTNnRwrSfLo5BNiltuD6OMaqHacF6ZYfJRltRY7XT831dOYBOxC7esLUpPoZnPF_oM8UGuOsX--AYCrLJJ
link.rule.ids 315,786,790,2782,27109,27957,27958,57093,57143
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT8MwDI5gHAYHHgPEeIwIce1o2iRtj2gwDdgmBJu025S0iTQeHVq7A_x6nD60Cg5wrZrIip34s-P4Q-gyYIIzKR0rtJmwqG8HsOcIs7RQfsi9SPtZQn8w5L0xvZ-wSdEmx7yFASESmCnJLvFX3QXI1YtiEDrYrruONpgHcbiBQZ3n1RtIz8nZ8UzJAeN-2UWoOtR4oDCpeKCKK-nu5JxEmRBZBclre5nKdvj1oz_j_6TcRdsFosTXuQnsoTUVN1C9UxK5NdBWpefgPnoyibCsIvYTizjCZV4Mg8Es3udRzlCf4LnGNzNTAAZCvgEgxbMYPuRsKil-XC6UGWqqJZMDNO7ejjo9qyBWsAREO6lFQHGu8uCcY0oHnEWhbWtPGLpxE-FQoRSEGa6i2tWC09BnMnD8iAs30IQH0j1EtXgeqyOENSFactCujgIqNfWpQwFzGBgA7lFFTdSCdZoWGyOZZnfeDsQc5UI10UWpjelH3mDj90_Hf81yjuq90aA_7d8NH07QJqAaZuq5CDlFtXSxVGeAHFLZykzmG7EnurQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3JTsMwEB1BkVgOLAVEWYqFuKZksZ3kiFoq1lIBlXqrnMSWypJWTXqAr2ecBSI4wDWKrZHH43kzHs8DOPWZ4CwIbCM0mTCoZ_pocxYzlJBeyN1IeVlC_67HLwf0esiGRaCo38KgEAnOlGSX-Nqqp5EqOgxYZ8-SYfhgOs4iLDFN3K2hUPvx-x2ka-cMebrsgHGv7CRUHaq9UJhUvFDFnXQ34P5LkKyK5KU1T4NW-PGjR-P_Jd2E9QJZkvN8K2zBgozrsNIuCd3qsFbpPbgNDzohllXGvhMRR6TMjxHcOLO3SZQz1SdkokhnrAvBUNBXBKZkHOOHnFUlJf35TOqhumoy2YFB9-KpfWkUBAuGwKgnNSxUoCNdPO-YVD5nUWiayhWadlxHOlRIieGGI6lylOA09Fjg217EheMri_uBswu1eBLLPSDKslTAUcsq8mmgqEdtithDwwF0kzJqQBPXalQYSDLK7r5tjD3KhWrASamR0TRvtPH7p_2_ZjmG5X6nO7q96t0cwCqCG6bLuizrEGrpbC6PEECkQTPbNZ_1zL0u
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Solubility+and+Solution+Thermodynamics+of+Diphenoxylate+in+Different+Pure+Solvents&rft.jtitle=Journal+of+chemical+and+engineering+data&rft.au=Qing%2C+Xue-Yan&rft.au=Fu%2C+Hua-Lin&rft.au=Shu%2C+Gang&rft.au=Liu%2C+Meng-Jiao&rft.date=2015-06-11&rft.pub=American+Chemical+Society&rft.issn=0021-9568&rft.eissn=1520-5134&rft_id=info:doi/10.1021%2Fje5010033&rft.externalDocID=d014295084
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9568&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9568&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9568&client=summon