Stimuli-Responsive Polymers for Advanced 19F Magnetic Resonance Imaging: From Chemical Design to Biomedical Applications
Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19F MRI tracers. Thes...
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Published in | Biomacromolecules Vol. 25; no. 9; pp. 5630 - 5649 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
American Chemical Society
09.09.2024
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Abstract | Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive 19F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in 19F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer 19F MRI tracers in the current context of polymer diagnostics research. |
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AbstractList | Fluorine magnetic resonance imaging (
19
F MRI)
is a rapidly
evolving research area with a high potential to advance the field
of clinical diagnostics. In this review, we provide an overview of
the recent progress in the field of fluorinated stimuli-responsive
polymers applied as
19
F MRI tracers. These polymers respond
to internal or external stimuli (e.g., temperature, pH, oxidative
stress, and specific molecules) by altering their physicochemical
properties, such as self-assembly, drug release, and polymer degradation.
Incorporating noninvasive
19
F labels enables us to track
the biodistribution of such polymers. Furthermore, by triggering polymer
transformation, we can induce changes in
19
F MRI signals,
including attenuation, amplification, and chemical shift changes,
to monitor alterations in the environment of the tracer. Ultimately,
this review highlights the emerging potential of stimuli-responsive
fluoropolymer
19
F MRI tracers in the current context of
polymer diagnostics research. Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive 19F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in 19F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer 19F MRI tracers in the current context of polymer diagnostics research. Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive 19F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in 19F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer 19F MRI tracers in the current context of polymer diagnostics research.Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this review, we provide an overview of the recent progress in the field of fluorinated stimuli-responsive polymers applied as 19F MRI tracers. These polymers respond to internal or external stimuli (e.g., temperature, pH, oxidative stress, and specific molecules) by altering their physicochemical properties, such as self-assembly, drug release, and polymer degradation. Incorporating noninvasive 19F labels enables us to track the biodistribution of such polymers. Furthermore, by triggering polymer transformation, we can induce changes in 19F MRI signals, including attenuation, amplification, and chemical shift changes, to monitor alterations in the environment of the tracer. Ultimately, this review highlights the emerging potential of stimuli-responsive fluoropolymer 19F MRI tracers in the current context of polymer diagnostics research. |
Author | Tunca Arın, Tuba Ayça Sedlacek, Ondrej |
AuthorAffiliation | Department of Physical and Macromolecular Chemistry, Faculty of Science |
AuthorAffiliation_xml | – name: Department of Physical and Macromolecular Chemistry, Faculty of Science |
Author_xml | – sequence: 1 givenname: Tuba Ayça orcidid: 0000-0003-2130-8330 surname: Tunca Arın fullname: Tunca Arın, Tuba Ayça – sequence: 2 givenname: Ondrej orcidid: 0000-0001-5731-2687 surname: Sedlacek fullname: Sedlacek, Ondrej email: sedlacek@natur.cuni.cz |
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Snippet | Fluorine magnetic resonance imaging (19F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this... Fluorine magnetic resonance imaging ( 19 F MRI) is a rapidly evolving research area with a high potential to advance the field of clinical diagnostics. In this... |
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Title | Stimuli-Responsive Polymers for Advanced 19F Magnetic Resonance Imaging: From Chemical Design to Biomedical Applications |
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