2‘-O-{2-[N,N-(Dialkyl)aminooxy]ethyl}- Modified Antisense Oligonucleotides
Oligonucleotides with two novel modifications, 2‘-O-{2-[N,N-(dimethyl)aminooxy]ethyl} (2‘-O-DMAOE) and 2‘-O-{2-[N,N-(diethyl)aminooxy]ethyl} (2‘-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and enhance the nuclease stability of oli...
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Published in | Organic letters Vol. 2; no. 25; pp. 3995 - 3998 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
14.12.2000
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | Oligonucleotides with two novel modifications, 2‘-O-{2-[N,N-(dimethyl)aminooxy]ethyl} (2‘-O-DMAOE) and 2‘-O-{2-[N,N-(diethyl)aminooxy]ethyl} (2‘-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and enhance the nuclease stability of oligonucleotides considerably with t 1/2 > 24 h as a phosphodiester. |
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ISSN: | 1523-7060 1523-7052 |
DOI: | 10.1021/ol006555g |