Fluorinated Glycopolymers as Reduction-responsive 19F MRI Agents for Targeted Imaging of Cancer

• Published in: Biomacromolecules Vol. 20; no. 5; pp. 2043 - 2050
• Main Authors: Fu, Changkui, Tang, Joyce, Pye, Aidan, Liu, Tianqing, Zhang, Cheng, Tan, Xiao, Han, Felicity, Peng, Hui, Whittaker, Andrew K
• Format: Journal Article
• Language: English
• Published: American Chemical Society 13.05.2019
• Subjects: crosslinking; disease and pest management; fluorine; glucose; glucose transporters; image analysis; magnetic resonance imaging; neoplasm cells; neoplasms; polymerization; polymers; stable isotopes
• ISSN: 1525-7797; 1526-4602; 1526-4602
• DOI: 10.1021/acs.biomac.9b00241

Imaging agents that can be targeted to specific diseases and respond to the microenvironment of the diseased tissue are of considerable interest due to their potential in diagnosing and managing diseases. Here we report a new class of branched fluorinated glycopolymers as 19F MRI contrast agents tha...