White Matter Correlates of Apathy in HIV-Positive Subjects: A Diffusion Tensor Imaging Study

Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric sy...

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Published inThe journal of neuropsychiatry and clinical neurosciences Vol. 22; no. 3; pp. 313 - 320
Main Authors Hoare, Jacqueline, Fouche, Jean-Paul, Spottiswoode, Bruce, Joska, John A, Schoeman, Renata, Stein, Dan J, Carey, Paul D
Format Journal Article
LanguageEnglish
Published Arlington, VA American Psychiatric Publishing, Inc 01.07.2010
American Psychiatric Publishing
Subjects
Biological and medical sciences
Human viral diseases
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Infection
Human
Apathy
Immunopathology
Viral disease
Medical imagery
AIDS
Nuclear magnetic resonance imaging
Immune deficiency
White matter
Diffusion tensor imaging
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Abstract Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric symptom. Thirteen HIV+ participants with apathy, 13 HIV+ participants with no apathy, and 10 healthy comparison subjects were examined using diffusion tensor imaging in the region of the anterior cingulate and corpus callosum. Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex.
AbstractList Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors aimed to determine whether apathy in HIV reflects a direct effect of the virus on subcortical brain regions or a secondary neuropsychiatric symptom. Thirteen HIV+ participants with apathy, 13 HIV+ participants with no apathy, and 10 healthy comparison subjects were examined using diffusion tensor imaging in the region of the anterior cingulate and corpus callosum. Results of the study confirmed the hypothesis which anticipated changes associated with apathy in white matter tracts that relay through the medial prefrontal cortex.
Author Stein, Dan J
Joska, John A
Schoeman, Renata
Carey, Paul D
Hoare, Jacqueline
Fouche, Jean-Paul
Spottiswoode, Bruce
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Cites_doi 10.1017/S1355617700633088
10.1080/13550280290049615
10.1176/jnp.8.1.41
10.1046/j.1440-1614.1999.00579.x
10.1176/ajp.147.1.22
10.1176/jnp.4.2.134
10.1136/jnnp.23.1.56
10.1002/nbm.1940080707
10.1016/S0925-4927(00)00082-2
10.1212/WNL.43.10.2099
10.1212/WNL.53.4.782
10.1002/mrm.1910360612
10.1016/j.acn.2005.06.007
10.1111/j.1750-3639.2003.tb00019.x
10.1089/108729103763807936
10.1111/j.1750-3639.1996.tb00775.x
10.1016/0165-1781(91)90040-V
10.1176/jnp.17.2.167
10.1176/jnp.17.1.114
10.1016/0166-2236(90)90107-L
10.1016/S0022-3999(02)00428-2
10.1111/j.1749-6632.1995.tb38127.x
10.1176/appi.ajp.2007.07010042
10.1176/appi.ajp.2007.07010043
10.1212/WNL.58.12.1764
10.1136/jnnp.72.6.742
10.1212/01.WNL.0000031811.45569.B0
10.7326/0003-4819-111-5-400
10.1097/00002030-199910010-00011
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Issue 3
Keywords Infection
Human
Apathy
Immunopathology
Viral disease
Medical imagery
AIDS
Nuclear magnetic resonance imaging
Immune deficiency
White matter
Diffusion tensor imaging
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References p_27
p_28
p_23
p_24
p_25
Thurner MM (p_20) 2005; 26
Andersson S (p_39) 2002; 15
Sheehan DV (p_22) 1998; 59
Cummings JL (p_3) 2003
Weschler D (p_29) 1987
Nath A (p_8) 2007
Wu Y (p_21) 2006; 27
McArthur J (p_33) 1994
p_16
p_38
p_17
p_2
p_18
p_1
p_19
p_4
p_12
p_13
p_35
p_6
p_14
p_36
p_5
p_15
p_37
p_7
p_9
p_30
p_31
Reuter-Lorenz PA (p_34) 2003
p_10
p_32
p_11
Sacktor NC (p_26) 2005; 19
References_xml – volume: 15
  start-page: 184
  year: 2002
  ident: p_39
  publication-title: Neuropsychiatry Neuropsychol Behav Neurol
– volume: 19
  start-page: 1367
  year: 2005
  ident: p_26
  publication-title: AIDS
– ident: p_13
  doi: 10.1017/S1355617700633088
– ident: p_1
  doi: 10.1080/13550280290049615
– ident: p_16
  doi: 10.1176/jnp.8.1.41
– ident: p_25
  doi: 10.1046/j.1440-1614.1999.00579.x
– ident: p_9
  doi: 10.1176/ajp.147.1.22
– ident: p_15
  doi: 10.1176/jnp.4.2.134
– volume: 26
  start-page: 2275
  year: 2005
  ident: p_20
  publication-title: AJNR Am J Neuroradiol
– volume-title: Mega MS: Neuropsychiatry and Behavioral Neuroscience
  year: 2003
  ident: p_3
– ident: p_24
  doi: 10.1136/jnnp.23.1.56
– volume-title: Tex
  year: 1987
  ident: p_29
– ident: p_17
  doi: 10.1002/nbm.1940080707
– ident: p_19
  doi: 10.1016/S0925-4927(00)00082-2
– start-page: 341
  volume-title: The Parallel Brain
  year: 2003
  ident: p_34
– ident: p_31
  doi: 10.1212/WNL.43.10.2099
– ident: p_4
  doi: 10.1212/WNL.53.4.782
– volume: 27
  start-page: 656
  year: 2006
  ident: p_21
  publication-title: AJNR Am J Neuroradiol
– ident: p_36
  doi: 10.1002/mrm.1910360612
– volume-title: Evolution of HIV Dementia with HIV infection
  year: 2007
  ident: p_8
– ident: p_30
  doi: 10.1016/j.acn.2005.06.007
– ident: p_7
  doi: 10.1111/j.1750-3639.2003.tb00019.x
– ident: p_14
  doi: 10.1089/108729103763807936
– start-page: 56
  volume-title: Neuropsychology of HIV Infection
  year: 1994
  ident: p_33
– ident: p_18
  doi: 10.1111/j.1750-3639.1996.tb00775.x
– ident: p_23
  doi: 10.1016/0165-1781(91)90040-V
– ident: p_10
  doi: 10.1176/jnp.17.2.167
– ident: p_11
  doi: 10.1176/jnp.17.1.114
– ident: p_38
  doi: 10.1016/0166-2236(90)90107-L
– ident: p_32
  doi: 10.1016/S0022-3999(02)00428-2
– ident: p_37
  doi: 10.1111/j.1749-6632.1995.tb38127.x
– ident: p_28
  doi: 10.1176/appi.ajp.2007.07010042
– volume: 59
  start-page: 22
  year: 1998
  ident: p_22
  publication-title: J Clin Psychiatry
– ident: p_27
  doi: 10.1176/appi.ajp.2007.07010043
– ident: p_2
  doi: 10.1212/WNL.58.12.1764
– ident: p_35
  doi: 10.1136/jnnp.72.6.742
– ident: p_5
  doi: 10.1212/01.WNL.0000031811.45569.B0
– ident: p_12
  doi: 10.7326/0003-4819-111-5-400
– ident: p_6
  doi: 10.1097/00002030-199910010-00011
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Snippet Apathy is commonly reported by patients infected with HIV. No previous work has assessed the relationship between white matter and apathy in HIV. The authors...
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SubjectTerms Biological and medical sciences
Human viral diseases
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Medical sciences
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Title White Matter Correlates of Apathy in HIV-Positive Subjects: A Diffusion Tensor Imaging Study
URI http://dx.doi.org/10.1176/jnp.2010.22.3.313
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