Discovery of STAT3 and Histone Deacetylase (HDAC) Dual-Pathway Inhibitors for the Treatment of Solid Cancer

• Published in: Journal of medicinal chemistry Vol. 64; no. 11; pp. 7468 - 7482
• Main Authors: Ren, Yuhao, Li, Shanshan, Zhu, Ren, Wan, Chengying, Song, Dongmei, Zhu, Jiawen, Cai, Guiping, Long, Sihui, Kong, Lingyi, Yu, Wenying
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 10.06.2021; Amer Chemical Soc
• Subjects: Chemistry, Medicinal; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; APOPTOSIS; ACTIVATION; DESIGN; THERAPY; GROWTH; DIFFERENTIATION; INDUCTION; PTEROSTILBENE; TRICHOSTATIN; HYBRIDS

Nowadays, simultaneous inhibition of multiple targets through drug combination is an important anticancer strategy owing to the complex mechanism behind tumorigenesis. Recent studies have demonstrated that the inhibition of histone deacetylases (HDACs) will lead to compensated activation of a notori...