Ti-Catalyzed Dehydroxylation of Tertiary Alcohols

• Published in: Organic letters Vol. 24; no. 46; pp. 8459 - 8464
• Main Authors: Lin, Quan, Tong, Weiqi, Shu, Xing-Zhong, Chen, Yunrong
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 25.11.2022; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; SITE-SELECTIVE DEOXYGENATION; FORMIC-ACID; TRANSFER HYDROGENOLYSIS; BENZYLIC ALCOHOLS; SECONDARY; BIO; ARYL; B(C6F5)-CATALYZED REDUCTION; CLEAVAGE; EFFICIENT

Herein we report a Ti-catalyzed direct dehydroxylation of tertiary aliphatic alcohols under mild reaction conditions, forging Barton-type deoxygenation products. This protocol tolerates a wide range of functional groups, including primary alkyl chloride and carbonyl groups. It allows for selective d...