2H‑Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

• Published in: Journal of the American Chemical Society Vol. 142; no. 13; pp. 6051 - 6059
• Main Authors: Ma, Nan, Hu, Jun, Zhang, Zhi-Min, Liu, Wenyan, Huang, Minhao, Fan, Youlong, Yin, Xingfeng, Wang, Jigang, Ding, Ke, Ye, Wencai, Li, Zhengqiu
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.04.2020; Amer Chemical Soc
• Subjects: chemical bonding; Chemistry; Chemistry, Multidisciplinary; chemoselectivity; cysteine; humans; lysine; Physical Sciences; Science & Technology; REACTIVITY

Protein modification by chemical reagents has played an essential role in the treatment of human diseases. However, the reagents currently used are limited to the covalent modification of cysteine and lysine residues. It is thus desirable to develop novel methods that can covalently modify other res...