The Tripartite Cascade Strategy Amplifies Cellular Oxidative Stress to Disrupt Oxidation–Reduction Homeostasis for Tumor Immunogenic Cell Death

• Published in: ACS materials letters Vol. 7; no. 3; pp. 730 - 740
• Main Authors: Jiang, Lingdong, Chen, Xiaojia, Gu, Yuqing, Deng, Fuan, Song, Yue, Mao, Chunping, Tong, Yuqi, Wang, Fengyi, Zhang, Wenyuan, Liu, Yujing, Chen, Yichi, Shi, Haonan, Zhang, Lu
• Format: Journal Article
• Language: English
• Published: American Chemical Society 03.03.2025

Immunogenic cell death (ICD) induced by intracellular oxidation–reduction homeostasis imbalance is a classic mechanism in cancer immunotherapy. Herein, we propose a tripartite strategy to amplify cellular oxidative stress based on a combination of peptidic nanoparticles (TPFNO/CCA NPs) of host–guest...