Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study

• Published in: ACS medicinal chemistry letters Vol. 8; no. 10; pp. 997 - 1001
• Main Authors: Marzo, Tiziano, Cirri, Damiano, Gabbiani, Chiara, Gamberi, Tania, Magherini, Francesca, Pratesi, Alessandro, Guerri, Annalisa, Biver, Tarita, Binacchi, Francesca, Stefanini, Matteo, Arcangeli, Annarosa, Messori, Luigi
• Format: Journal Article
• Language: English
• Published: American Chemical Society 12.10.2017
• Subjects: Letter; colorectal cancer; protein interaction; in vivo experiments; DNA interaction; anticancer drugs; thioredoxin reductase; Auranofin

The solution behavior of auranofin, Et3PAuCl  and Et3PAuI, as well as their interactions with hen egg white lysozyme, single strand oligonucleotide, and ds-DNA were comparatively analyzed through NMR spectroscopy, ESI-MS, ethidium bromide displacement, DNA melting and viscometric tests. The cytotoxi...