Derivatization-Based Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Folate Species: A Cost-Effective Method for the Health Food Industry

• Published in: ACS food science & technology Vol. 5; no. 5; pp. 1910 - 1917
• Main Authors: Wang, Hung-Cheng, Yamamoto, Atsushi, Chang, Yongjin, Kawai, Yasushi, Rakhimuzzaman, Md, Emi, Takashi
• Format: Journal Article
• Language: English
• Published: American Chemical Society 16.05.2025
• Subjects: deconjugation; LC-MS/MS; folate; yeast extract; derivatization

Folates are crucial for one-carbon (C1) metabolism, with C1-modified tetrahydrofolate (C1-THF) exhibiting superior functionality. However, analysis of these compounds is challenging because of their low stability. This study presents a novel chemical derivatization-based liquid chromatography-tandem...