T rosettes in alcoholic cirrhosis of the liver

Thirty patients with alcoholic cirrhosis of the liver were studied for in vivo and in vitro correlates of cellular immunity. Seventy-seven percent failed to be sensitized to dinitrochlorobenzene, indicating impairment of the in vivo cellular immune response. A significant decrease in the number of T...

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Bibliographic Details
Published inJAMA : the journal of the American Medical Association Vol. 232; no. 1; p. 44
Main Authors Berenyi, M R, Straus, B, Avila, L
Format Journal Article
LanguageEnglish
Published United States 07.04.1975
Subjects
Alcoholism - complications
Antigens, Fungal - administration & dosage
Candida albicans - immunology
Female
Humans
Hypersensitivity, Delayed - immunology
Immune Adherence Reaction
Immunity, Cellular
Immunization
Informed Consent
Lectins
Liver - immunology
Liver Cirrhosis - immunology
Lymphocyte Activation
Male
Nitrobenzenes - immunology
Skin - immunology
Skin Tests
Streptodornase and Streptokinase - immunology
T-Lymphocytes - immunology
Time Factors
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Summary:Thirty patients with alcoholic cirrhosis of the liver were studied for in vivo and in vitro correlates of cellular immunity. Seventy-seven percent failed to be sensitized to dinitrochlorobenzene, indicating impairment of the in vivo cellular immune response. A significant decrease in the number of T-rosette-forming cells was observed in this group of patients (.01 smaller than P smaller than .025). This finding suggests that the active T-rosette test is a valuable tool in detecting partial alterations in cell-mediated immunity in alcoholic cirrhosis of the liver. Our results also suggest that rosette formation is a more sensitive indicator of cell-mediated immunity than phytohemagglutinin-stimulated blastogenesis in patients with alcoholic cirrhosis of the liver.
ISSN:0098-7484
DOI:10.1001/jama.1975.03250010026019