I2‑Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions

• Published in: Journal of organic chemistry Vol. 82; no. 24; pp. 13632 - 13642
• Main Authors: Nageswara Rao, Sadu, Reddy, N. Naresh Kumar, Samanta, Supravat, Adimurthy, Subbarayappa
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.12.2017
• Subjects: amines; benzamides; carbon; chemical bonding; chemical structure; cleavage (chemistry); cyanides; iodine; organic chemistry; oxidants; oxidation; surveys

We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C–H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature s...