I2‑Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions
We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C–H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature s...
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| Published in | Journal of organic chemistry Vol. 82; no. 24; pp. 13632 - 13642 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
American Chemical Society
15.12.2017
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C–H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions. |
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| AbstractList | We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions.We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions. We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I₂ and TBHP as the green oxidant via the C–H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions. We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2 and TBHP as the green oxidant via the C–H bond cleavage of the benzylic carbon under mild reaction conditions. According to the literature survey, this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyanides in one pot under metal-free conditions. |
| Author | Nageswara Rao, Sadu Adimurthy, Subbarayappa Samanta, Supravat Reddy, N. Naresh Kumar |
| AuthorAffiliation | Academy of Scientific & Innovative Research |
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| Author_xml | – sequence: 1 givenname: Sadu surname: Nageswara Rao fullname: Nageswara Rao, Sadu – sequence: 2 givenname: N. Naresh Kumar surname: Reddy fullname: Reddy, N. Naresh Kumar – sequence: 3 givenname: Supravat surname: Samanta fullname: Samanta, Supravat – sequence: 4 givenname: Subbarayappa orcidid: 0000-0001-5320-4961 surname: Adimurthy fullname: Adimurthy, Subbarayappa email: adimurthy@csmcri.res.in |
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| Snippet | We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I2... We report a novel and efficient method for the oxidation of benzylic carbons (amines and cyanides) into corresponding benzamides using a catalytic amount of I₂... |
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| SubjectTerms | amines benzamides carbon chemical bonding chemical structure cleavage (chemistry) cyanides iodine organic chemistry oxidants oxidation surveys |
| Title | I2‑Catalyzed Oxidative Amidation of Benzylamines and Benzyl Cyanides under Mild Conditions |
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