New Mechanistic Insights into the Copper-Free Heck–Cassar–Sonogashira Cross-Coupling Reaction

• Published in: ACS catalysis Vol. 13; no. 18; pp. 12048 - 12061
• Main Authors: Palladino, Chiara, Fantoni, Tommaso, Ferrazzano, Lucia, Muzzi, Beatrice, Ricci, Antonio, Tolomelli, Alessandra, Cabri, Walter
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.09.2023
• Subjects: Heck−Cassar−Sonogashira reaction; palladium; cross-coupling reaction; mechanism; copper-free

The copper-free Heck–Cassar–Sonogashira (HCS) reaction, known since 1975, nowadays represents one of the most powerful methods for C–C bond formation in organic synthesis with several industrial applications. Despite its great success, the mechanism is still under discussion, with several reported p...