Pd-Catalyzed Regioselective Si–C Bond Cleavage: Maximizing Chemo-Divergence in (4 + 2) Silacyclization Reactions of Alkynals

• Published in: ACS catalysis Vol. 15; no. 12; pp. 10808 - 10817
• Main Authors: Wang, Xing-Ben, Si, Jia-Wei, Pu, Meng-Ling, Guo, Jun-Jie, Xu, Zheng, Li, Li, Shi, Zhuangzhi, Kwong, Fuk Yee, Xu, Li-Wen
• Format: Journal Article
• Language: English
• Published: American Chemical Society 20.06.2025
• Subjects: palladium catalysis; silacycles; Si−C bond activation; cyclization; divergent catalysis

Precise control of catalyst systems to achieve chemodivergent synthesis from identical starting materials remains a fundamental challenge in catalysis and synthetic chemistry. Herein, we report a ligand-driven Pd-catalyzed regio- and chemodivergent (4 + 2) silacyclization reactions of benzosilacyclo...