6価クロムによるマウスの生体内脂質過酸化促進と毒性との関係
6価(K2Cr2O7)および3価クロム(Cr(NO3)3)を腹腔内投与(20mgCr/kg)したマウスにおける, 組織内の脂質過酸化(チオバルビツール酸反応物質)と組織障害との関連性について検討し, 以下の成績を得た. (1) 6価クロムは, 肝臓内脂質過酸化を著明に促進し, 腎臓内のこれを僅かに促進したが, 3価クロムは, これらを促進し得なかった. (2) 6価クロム投与マウスの肝および腎臓内クロム含量は, 3価クロム投与マウスのそれらより高かった. (3) 還元剤であるL-アスコルビン酸は, 6価クロムによって誘起された組織内脂質過酸化の促進, 組織内クロム蓄積, 肝臓(血清オルニチン・...
Saved in:
| Published in | Japanese journal of veterinary science Vol. 51; no. 6; pp. 1103 - 1110 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本獣医学会
1989
|
| Online Access | Get full text |
| ISSN | 0021-5295 1881-1442 |
| DOI | 10.1292/jvms1939.51.1103 |
Cover
| Abstract | 6価(K2Cr2O7)および3価クロム(Cr(NO3)3)を腹腔内投与(20mgCr/kg)したマウスにおける, 組織内の脂質過酸化(チオバルビツール酸反応物質)と組織障害との関連性について検討し, 以下の成績を得た. (1) 6価クロムは, 肝臓内脂質過酸化を著明に促進し, 腎臓内のこれを僅かに促進したが, 3価クロムは, これらを促進し得なかった. (2) 6価クロム投与マウスの肝および腎臓内クロム含量は, 3価クロム投与マウスのそれらより高かった. (3) 還元剤であるL-アスコルビン酸は, 6価クロムによって誘起された組織内脂質過酸化の促進, 組織内クロム蓄積, 肝臓(血清オルニチン・カルバミル・トランスフェラーゼ活性の増加)および腎臓障害(血清尿素窒素量の増加)をそれぞれ抑制した. (4) 抗酸化剤であるN, N'-ジフェニル-p-フェニレンジアミンは, 6価クロムによる組織内の脂質過酸化促進を抑制したが, クロムの蓄積および組織障害を抑制し得なかった. 以上の成績から, 6価クロムは組織内の脂質過酸化を促進することが明らかとなったが, 認められた脂質過酸化の促進は, 6価クロムの毒性発現に直接関与しないことが示唆された. |
|---|---|
| AbstractList | 6価(K2Cr2O7)および3価クロム(Cr(NO3)3)を腹腔内投与(20mgCr/kg)したマウスにおける, 組織内の脂質過酸化(チオバルビツール酸反応物質)と組織障害との関連性について検討し, 以下の成績を得た. (1) 6価クロムは, 肝臓内脂質過酸化を著明に促進し, 腎臓内のこれを僅かに促進したが, 3価クロムは, これらを促進し得なかった. (2) 6価クロム投与マウスの肝および腎臓内クロム含量は, 3価クロム投与マウスのそれらより高かった. (3) 還元剤であるL-アスコルビン酸は, 6価クロムによって誘起された組織内脂質過酸化の促進, 組織内クロム蓄積, 肝臓(血清オルニチン・カルバミル・トランスフェラーゼ活性の増加)および腎臓障害(血清尿素窒素量の増加)をそれぞれ抑制した. (4) 抗酸化剤であるN, N'-ジフェニル-p-フェニレンジアミンは, 6価クロムによる組織内の脂質過酸化促進を抑制したが, クロムの蓄積および組織障害を抑制し得なかった. 以上の成績から, 6価クロムは組織内の脂質過酸化を促進することが明らかとなったが, 認められた脂質過酸化の促進は, 6価クロムの毒性発現に直接関与しないことが示唆された. |
| Author | 古川, 義宣 道場, 尚輝 箕浦, 清二郎 諏佐, 信行 上野, 俊治 |
| Author_xml | – sequence: 1 fullname: 上野, 俊治 – sequence: 1 fullname: 古川, 義宣 – sequence: 1 fullname: 道場, 尚輝 – sequence: 1 fullname: 諏佐, 信行 – sequence: 1 fullname: 箕浦, 清二郎 |
| BackLink | https://agriknowledge.affrc.go.jp/RN/2030450696$$DView record in AgriKnowledge |
| BookMark | eNo9UEtLAlEUvoRBZu37E2P3Ma-7DLEHCG1yfbkz3msz-WJGinY6ZgRFiwqXvRYVRQm1qUX5Y66a_otGrDbnHM73OJxvHiQq1YoAYAnBNMIUL_u75RBRQtMGSiMEyQxIIttGGtJ1nABJCDHSDEyNOTAfhj6EOrWhlQR5s_91o6Kuaj2r1rVqPqnoSEXHqnWpojsVfajmy_fFVf_zfHDYHh1Eo7fHcfN03H4fnHT6vda48aqaD8Pu2bBxHw8xedy57feiBTAreSkUi789BfKr2a3MupbbXNvIrOQ0jgnhGpcFLLmJbaEjR5jUgXZBcgdZthTINYWkls2FDbE0HQQFpoRQhwtpOfGe6DpJAWvqy6UMvDrjxcDbqVT3SqJQFKzKPTYBXFasMr_GIGLx32Z8z4iV2anSD-s85tYCr8yDfcaDuueWBPuLkxmImdMySfUfd7d5wHxOfgB3IpEY |
| ContentType | Journal Article |
| Copyright | 社団法人 日本獣医学会 |
| Copyright_xml | – notice: 社団法人 日本獣医学会 |
| DBID | N5S |
| DOI | 10.1292/jvms1939.51.1103 |
| DatabaseName | AgriKnowledge（アグリナレッジ）AGROLib |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1881-1442 |
| EndPage | 1110 |
| ExternalDocumentID | oai_affrc_go_jp_01_00466285 article_jvms1939_51_6_51_6_1103_article_char_ja |
| GroupedDBID | -~X 2WC AI. ALMA_UNASSIGNED_HOLDINGS B.T F5P JSF KQ8 N5S OK1 RJT TKC VH1 |
| ID | FETCH-LOGICAL-a233a-afd2fa628e41be69b08dfab178fe1c6ef978ae802f6b10e29339baef7b78a3443 |
| ISSN | 0021-5295 |
| IngestDate | Fri Aug 15 12:22:21 EDT 2025 Wed Sep 03 06:28:51 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Issue | 6 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-a233a-afd2fa628e41be69b08dfab178fe1c6ef978ae802f6b10e29339baef7b78a3443 |
| Notes | ZZ00004647 450696 |
| OpenAccessLink | https://agriknowledge.affrc.go.jp/RN/2030450696 |
| PageCount | 8 |
| ParticipantIDs | affrit_agriknowledge_oai_affrc_go_jp_01_00466285 jstage_primary_article_jvms1939_51_6_51_6_1103_article_char_ja |
| PublicationCentury | 1900 |
| PublicationDate | 1989 |
| PublicationDateYYYYMMDD | 1989-01-01 |
| PublicationDate_xml | – year: 1989 text: 1989 |
| PublicationDecade | 1980 |
| PublicationTitle | Japanese journal of veterinary science |
| PublicationTitleAlternate | 日本獸醫學雜誌 |
| PublicationYear | 1989 |
| Publisher | 公益社団法人 日本獣医学会 |
| Publisher_xml | – name: 公益社団法人 日本獣医学会 |
| References | 8. Hasan, M. and Ali, F. 1981. Effects of thallium, nickel, and cobalt administration on lipid peroxidation in different regions of the rat brain. Toxicol. Appl. Pharmacol. 5: 8-13. 26. Susa, N., Furukawa, Y., and Tsubaki, S. 1977. Comparative cytotoxic effects of hexavalent and trivalent chromium compounds on cultured cells. Jpn. J. Vet. Sci. 39: 325-336 (in Japanese with English summary). 15. Mathur, A. K., Chandra, S. V., and Tandon, S. K. 1977. Comparative toxicity of trivalent and hexavalent chromium to rabbits. II. Morphological changes in some organs. Toxicology 8: 53-61. 25. Stroo, W. E. and Hook, J. B. 1977. Enzymes of renal original in urine as indicators of nephrotoxicity. Toxicol. Appl. Pharmacol. 63: 29-35. 13. Langard, S. and Norseth, T. 1979. Chromium. pp. 383-397. In: Handbook on the Toxicology of Metals (Friberg, L., Nordberg, G. F., and Vouk, B. eds.), Elsevier/North-Holland, Biochemical Press, Amsterdam. 9. Hussain, T., Ali, M. M., and Chandra, S. V. 1985. Effect of cadmium exposure on lipids, and lipid peroxidation and metal distribution in rat brain regions. Ind. Health 23: 199-205. 14. Leung, H. -W., Vang, M. J., and Mavis, R. D. 1981. The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipid. Biochem. Biophys. Acta 664: 266-272. 17. Pirozzi, D. J., Gross, P. R., and Samitz, M. H. 1968. The effect of ascorbic acid on chrome ulcers in guinea pigs. Arch. Environ. Health 17: 178-180. 18. Plaa, G. L. and Witschi, H. 1976. Chemical, Drugs, and lipid peroxidation. Annu. Rev. Pharmacol. Toxicol. 16: 125-141. 20. Samitz, M. H. and Katz, S. 1965. Protection against inhalation of chromic acid mist. Use of filters impregnated with ascorbic acid. Arch. Environ. Health 11: 770-772. 5. Drotman, R. B. and Lawborn, G. T. 1978. Serum enzymes as indicators of chemically induced liver damage. Drug Chem. Toxicol. 1: 163-171. 23. Stacey, N. H. and kappus, H. 1982. Cellular toxicity and lipid peroxidation in response to mercury. Toxicol. Appl. Pharmacol. 63: 29-35. 2. Carson, B. L., Ellis III, H. V., and McConn, J. L. 1986. pp. 68-74. In: Toxicology and Biological Monitoring of Metals in Humans. Lewis Publishers, INC. Michigan. 7. Haase, G. and Dunkley, W. L. 1968. Ascorbic acid and copper in linoleate oxidation. II. Ascorbic acid and copper as oxidation catalysis. J. Lipid Res. 10: 561-567. 16. Merts, W. 1968. Chromium occurrence and function in biological systems. Physiol. Rev. 49: 163-239. 27. Uchiyama, M. and Mihara, M. 1978. Determination of malonaldehyde precurser in tissues by thiobarbituric acid test. Anal. Biochem. 86: 271-278. 32. Yonaha, M., Ohbayashi, Y., Noto, N., Itoh, E., and Uchiyama, M. 1980. Effects of trivalent and hexavalent chromium on lipid peroxidation in rat liver microsomes. Chem. Pharm. Bull. 28: 893-899. 1. Anundi, I., Hogberg, J., and Stead, A. H. 1979. Glutathione depletion in isolated hypatocytes: Its relation to lipid peroxidation. Acta Pharmacol. et Toxicol. 45: 45-51. 33. Yonaha, M., Saito, M., and Sagai, M. 1983. Stimulation of lipid peroxidation by methylmercury in rats. Life Sci. 32: 1507-1514. 30. Welsh, S. O. 1979. The protective effect of vitamin E and N, N'-diphenyl-p-phenyl-enediamine (DPPD) against methyl mercury toxicity in the rat. J. Nutr. 109: 1673-1681. 21. Samitz, M. H., Scheiner, D. M., and Katz, S. A. 1968. Ascorbic acid in the prevention of chrome dermatitis: Mechanism of inactivation of chromium. Arch. Environ. Health 17: 44-45. 3. Christophersen, B. O. 1968. The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria. Biochem. J. 106: 515-522. 29. Utley, H. G., Bernheim, F., and Hochstein, P. 1967. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 118: 29-32. 22. Stacey, N. H., Cantilena, L. R. Jr., and Klassen, C. D. 1980. Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 53: 470-480. 10. Jennette, K. W. 1979. Chromate metabolism in liver microsomes. Trace Element Res. 1: 55-62. 24. Stacey, N. H. and Klaassen, C. D. 1981. Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. J. Toxicol. Environ. Health 7: 139-147. 28. Ueno, S., Susa, N., Furukawa, Y., Aikawa, K., Itagaki, I., Komiyama, T., and Takashima, Y. 1988. Effect of chromium on lipid peroxidation in isolated rat hepatocytes. Jpn. J. Vet. Sci. 50: 45-52. 31. Yonaha, M., Ohbayashi, Y., Ichinose, T., and Sagai, M. 1982. Lipid peroxidation stimulated by mercuric chloride and its relation to the toxicity .Chem. Pharm. Bull. 30: 1437-1442. 6. Gstraunthaler, G., Pfaller, W., and Katanko, P. 1983. Glutathione depletion and in vitro lipid peroxidation in mercury or maleate induced acute renal failure. Biochem. Pharmacol. 32: 2969-2972. 11. Korallus, U., Harzdorf, C., and Lewalter, J. 1984. Experimental bases for ascorbic acid therapy of poisoning by hexavalent chromium compounds. Ind. Arch. Occup. Environ. Health 53: 247-256. 4. Dillard, C. J. and Tappel, A. L. 1984. Lipid peroxidation and copper in rat. Drug Chem. Toxicol. 7: 477-487. 19. Rana, S. V. S. and Kumar, A. 1984. Significance of lipid peroxidation in liver injury after heavy metal poisoning in rats. Current Sci. 53: 933-934. 12. Laborda, R., Diaz-Mayans, J., and Nunez, A. 1986. Nephrotoxic and hepatotoxic effects of chromium compounds in rats. Bull. Environ. Contam. Toxicol. 36: 332-336. |
| References_xml | – reference: 27. Uchiyama, M. and Mihara, M. 1978. Determination of malonaldehyde precurser in tissues by thiobarbituric acid test. Anal. Biochem. 86: 271-278. – reference: 23. Stacey, N. H. and kappus, H. 1982. Cellular toxicity and lipid peroxidation in response to mercury. Toxicol. Appl. Pharmacol. 63: 29-35. – reference: 19. Rana, S. V. S. and Kumar, A. 1984. Significance of lipid peroxidation in liver injury after heavy metal poisoning in rats. Current Sci. 53: 933-934. – reference: 9. Hussain, T., Ali, M. M., and Chandra, S. V. 1985. Effect of cadmium exposure on lipids, and lipid peroxidation and metal distribution in rat brain regions. Ind. Health 23: 199-205. – reference: 33. Yonaha, M., Saito, M., and Sagai, M. 1983. Stimulation of lipid peroxidation by methylmercury in rats. Life Sci. 32: 1507-1514. – reference: 12. Laborda, R., Diaz-Mayans, J., and Nunez, A. 1986. Nephrotoxic and hepatotoxic effects of chromium compounds in rats. Bull. Environ. Contam. Toxicol. 36: 332-336. – reference: 14. Leung, H. -W., Vang, M. J., and Mavis, R. D. 1981. The cooperative interaction between vitamin E and vitamin C in suppression of peroxidation of membrane phospholipid. Biochem. Biophys. Acta 664: 266-272. – reference: 31. Yonaha, M., Ohbayashi, Y., Ichinose, T., and Sagai, M. 1982. Lipid peroxidation stimulated by mercuric chloride and its relation to the toxicity .Chem. Pharm. Bull. 30: 1437-1442. – reference: 1. Anundi, I., Hogberg, J., and Stead, A. H. 1979. Glutathione depletion in isolated hypatocytes: Its relation to lipid peroxidation. Acta Pharmacol. et Toxicol. 45: 45-51. – reference: 29. Utley, H. G., Bernheim, F., and Hochstein, P. 1967. Effect of sulfhydryl reagents on peroxidation in microsomes. Arch. Biochem. Biophys. 118: 29-32. – reference: 32. Yonaha, M., Ohbayashi, Y., Noto, N., Itoh, E., and Uchiyama, M. 1980. Effects of trivalent and hexavalent chromium on lipid peroxidation in rat liver microsomes. Chem. Pharm. Bull. 28: 893-899. – reference: 10. Jennette, K. W. 1979. Chromate metabolism in liver microsomes. Trace Element Res. 1: 55-62. – reference: 22. Stacey, N. H., Cantilena, L. R. Jr., and Klassen, C. D. 1980. Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 53: 470-480. – reference: 15. Mathur, A. K., Chandra, S. V., and Tandon, S. K. 1977. Comparative toxicity of trivalent and hexavalent chromium to rabbits. II. Morphological changes in some organs. Toxicology 8: 53-61. – reference: 21. Samitz, M. H., Scheiner, D. M., and Katz, S. A. 1968. Ascorbic acid in the prevention of chrome dermatitis: Mechanism of inactivation of chromium. Arch. Environ. Health 17: 44-45. – reference: 8. Hasan, M. and Ali, F. 1981. Effects of thallium, nickel, and cobalt administration on lipid peroxidation in different regions of the rat brain. Toxicol. Appl. Pharmacol. 5: 8-13. – reference: 28. Ueno, S., Susa, N., Furukawa, Y., Aikawa, K., Itagaki, I., Komiyama, T., and Takashima, Y. 1988. Effect of chromium on lipid peroxidation in isolated rat hepatocytes. Jpn. J. Vet. Sci. 50: 45-52. – reference: 3. Christophersen, B. O. 1968. The inhibitory effect of reduced glutathione on the lipid peroxidation of the microsomal fraction and mitochondria. Biochem. J. 106: 515-522. – reference: 11. Korallus, U., Harzdorf, C., and Lewalter, J. 1984. Experimental bases for ascorbic acid therapy of poisoning by hexavalent chromium compounds. Ind. Arch. Occup. Environ. Health 53: 247-256. – reference: 17. Pirozzi, D. J., Gross, P. R., and Samitz, M. H. 1968. The effect of ascorbic acid on chrome ulcers in guinea pigs. Arch. Environ. Health 17: 178-180. – reference: 5. Drotman, R. B. and Lawborn, G. T. 1978. Serum enzymes as indicators of chemically induced liver damage. Drug Chem. Toxicol. 1: 163-171. – reference: 7. Haase, G. and Dunkley, W. L. 1968. Ascorbic acid and copper in linoleate oxidation. II. Ascorbic acid and copper as oxidation catalysis. J. Lipid Res. 10: 561-567. – reference: 30. Welsh, S. O. 1979. The protective effect of vitamin E and N, N'-diphenyl-p-phenyl-enediamine (DPPD) against methyl mercury toxicity in the rat. J. Nutr. 109: 1673-1681. – reference: 18. Plaa, G. L. and Witschi, H. 1976. Chemical, Drugs, and lipid peroxidation. Annu. Rev. Pharmacol. Toxicol. 16: 125-141. – reference: 26. Susa, N., Furukawa, Y., and Tsubaki, S. 1977. Comparative cytotoxic effects of hexavalent and trivalent chromium compounds on cultured cells. Jpn. J. Vet. Sci. 39: 325-336 (in Japanese with English summary). – reference: 24. Stacey, N. H. and Klaassen, C. D. 1981. Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. J. Toxicol. Environ. Health 7: 139-147. – reference: 20. Samitz, M. H. and Katz, S. 1965. Protection against inhalation of chromic acid mist. Use of filters impregnated with ascorbic acid. Arch. Environ. Health 11: 770-772. – reference: 6. Gstraunthaler, G., Pfaller, W., and Katanko, P. 1983. Glutathione depletion and in vitro lipid peroxidation in mercury or maleate induced acute renal failure. Biochem. Pharmacol. 32: 2969-2972. – reference: 25. Stroo, W. E. and Hook, J. B. 1977. Enzymes of renal original in urine as indicators of nephrotoxicity. Toxicol. Appl. Pharmacol. 63: 29-35. – reference: 2. Carson, B. L., Ellis III, H. V., and McConn, J. L. 1986. pp. 68-74. In: Toxicology and Biological Monitoring of Metals in Humans. Lewis Publishers, INC. Michigan. – reference: 13. Langard, S. and Norseth, T. 1979. Chromium. pp. 383-397. In: Handbook on the Toxicology of Metals (Friberg, L., Nordberg, G. F., and Vouk, B. eds.), Elsevier/North-Holland, Biochemical Press, Amsterdam. – reference: 16. Merts, W. 1968. Chromium occurrence and function in biological systems. Physiol. Rev. 49: 163-239. – reference: 4. Dillard, C. J. and Tappel, A. L. 1984. Lipid peroxidation and copper in rat. Drug Chem. Toxicol. 7: 477-487. |
| SSID | ssj0049807 ssib005879732 ssib002221906 ssib023157111 ssib000936952 ssib002223862 ssib023160888 ssib003105242 ssib003109985 |
| Score | 1.2513815 |
| Snippet | 6価(K2Cr2O7)および3価クロム(Cr(NO3)3)を腹腔内投与(20mgCr/kg)したマウスにおける, 組織内の脂質過酸化(チオバルビツール酸反応物質)と組織障害との関連性について検討し, 以下の成績を得た. (1) 6価クロムは, 肝臓内脂質過酸化を著明に促進し, 腎臓内のこれを僅かに促進したが,... |
| SourceID | affrit jstage |
| SourceType | Open Access Repository Publisher |
| StartPage | 1103 |
| Title | 6価クロムによるマウスの生体内脂質過酸化促進と毒性との関係 |
| URI | https://www.jstage.jst.go.jp/article/jvms1939/51/6/51_6_1103/_article/-char/ja https://agriknowledge.affrc.go.jp/RN/2030450696 |
| Volume | 51 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | 日本獸醫學雜誌(The Japanese Journal of Veterinary Science), 1989/12/15, Vol.51(6), pp.1103-1110 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Na9RAFA-lXryIomL9ogfnVFKTSWYycxEmu1mKoiC02ltIdpPigm2prQdP7daKoHhQ6dGvg4qiBb3oQfvHZFu7_4XvTZLdVCtYhSW8zLyZ_Oa9yb73kjcTwzgX26nVguDYbCUpNV3qpaZMUm46sRtHrpDcjXG98-UrfGLKvTjNpoeGr1eylpYW4_HmnT3XlfyLVqEM9IqrZPeh2X6nUAA06BeOoGE4_pWOOQlc4gdE2SRwiKBENTThEFUvCUsTNlF-wSNESfgFjwzK5rwgfFm2giqPSJfIhr5WnUiHBIwITgQjgSDCRX4gfLiWIoHEViLQBCO-0Mw1InOoDbwcVlnEp-UlgIcjckmRgCrlVar6MCR2omjZD6261dhQekQxTdSIqiFsUdcAJKLF4TMUS14ifWQD2IAZ4FGhl8iB44Af5ByreOnXMF0oX7Nc_A1Wnp1oLCCDfNwejhtmbIlQIRgYpu8P-EEYDaJcJHyQaz3n97QSpUYIhDPg1-LMRQ6a9N2cHxpbRCotdpBtfcAvcKCiryurggcnicCjqA0e9WAuW_-21PBYITyQEI7AQ7SADqqgRDl6TDBlmO5VwW_sj8JXTqF9vxS-yqcBYFZVc0ltE98E585CbiGFsE2IwneZ0GLP4Bu_2UNwLp2KbwWG1drTblOJ-wC3b9-8BQGFHGf2-KDlrt3Qi3stLFlDZoc8P2CLsKzHNYthGwKnA9TzbMz1vXS1EnfgZyxZJZ2AguGuphuA0ywq-2hCDMSou-tcysqmT0x4uOtVeQ4xE_PsgeGEcw7WvP9605XFPg6lfIv8CZDC-V9lAJ5xlKYLNzDubUPAWCabav938rBxqLglRlU-8iPGUDs6akzx7veXWWcjW_2Qrb7IVt5nnftZ50G2-izrvM46X7OVjz-ePu9-e7J1b23nbmfn87veyqPe2peth-vdzdXe8qds5e32xuPt5TdAAHNv_VV3s3PMmGoEk7UJs_hQixlRx4nMKG3RNOJUJK4dJ1zGlmilUWx7Ik3sJk9S6YkoERZNeWxbCUQYjoyjJPViKHdc1zluDM_OzSYnjFGIXmzJkoSxNHE5a8kmiy2v6cVN3uSiyUYMKxdHGM0sDN47hHqXfKhohjNzYXs-tOwQH_3hAvER40IuuHA-38An3OckOvm_HZwyDuapqfjk9rQxvLiwlJyBWGYxPqvn5U-oTg7t |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=6%E4%BE%A1%E3%82%AF%E3%83%AD%E3%83%A0%E3%81%AB%E3%82%88%E3%82%8B%E3%83%9E%E3%82%A6%E3%82%B9%E3%81%AE%E7%94%9F%E4%BD%93%E5%86%85%E8%84%82%E8%B3%AA%E9%81%8E%E9%85%B8%E5%8C%96%E4%BF%83%E9%80%B2%E3%81%A8%E6%AF%92%E6%80%A7%E3%81%A8%E3%81%AE%E9%96%A2%E4%BF%82&rft.jtitle=%E6%97%A5%E6%9C%AC%E7%8D%B8%E9%86%AB%E5%AD%B8%E9%9B%9C%E8%AA%8C%28The+Japanese+Journal+of+Veterinary+Science%29&rft.au=%E4%B8%8A%E9%87%8E%2C+%E4%BF%8A%E6%B2%BB&rft.au=%E5%8F%A4%E5%B7%9D%2C+%E7%BE%A9%E5%AE%A3&rft.au=%E9%81%93%E5%A0%B4%2C+%E5%B0%9A%E8%BC%9D&rft.au=%E8%AB%8F%E4%BD%90%2C+%E4%BF%A1%E8%A1%8C&rft.date=1989&rft.pub=%E5%85%AC%E7%9B%8A%E7%A4%BE%E5%9B%A3%E6%B3%95%E4%BA%BA+%E6%97%A5%E6%9C%AC%E7%8D%A3%E5%8C%BB%E5%AD%A6%E4%BC%9A&rft.issn=0021-5295&rft.eissn=1881-1442&rft.volume=51&rft.issue=6&rft.spage=1103&rft.epage=1110&rft_id=info:doi/10.1292%2Fjvms1939.51.1103&rft.externalDocID=article_jvms1939_51_6_51_6_1103_article_char_ja |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-5295&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-5295&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-5295&client=summon |