Three Polymorphs and Two Hydrates of a Multidrug Crystal Involving Gefitinib and Rhein: Characterization, Stability, and Solubility Aspects

• Published in: Crystal growth & design Vol. 24; no. 11; pp. 4501 - 4509
• Main Authors: Zhang, Fang, Long, Xiang-Tian, Ren, Bo-Ying, Dai, Xia-Lin, Lu, Tong-Bu, Chen, Jia-Mei
• Format: Journal Article
• Language: English
• Published: American Chemical Society 05.06.2024

Multidrug crystals, comprising multiple drugs in the same crystal lattice, can be used to develop drug combinations with improved physicochemical properties. The investigation on polymorphism of a given multidrug crystal aids in finding the optimal solid form for the development of combined formulat...