Nucleophilic Substitution of gem-Difluoroalkenes with TMSNu Promoted by Catalytic Amounts of Cs2CO3

• Published in: Journal of organic chemistry Vol. 84; no. 11; pp. 6557 - 6564
• Main Authors: Jiang, Ling-Feng, Ren, Bing-Tao, Li, Bin, Zhang, Guang-Yi, Peng, Yi, Guan, Zhen-Yu, Deng, Qing-Hai
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 07.06.2019; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; MILD; STEREOSELECTIVE CYANATION; ALPHA-FLUORO; DERIVATIVES; F BOND ACTIVATION; TRIFLUOROMETHYLATION

The efficient and practical nucleophilic cyanation and trifluoromethylation with appropriate trimethylsilyl nucleophiles were developed. Catalytic amounts of cheap and nontoxic Cs2CO3 were used to maintain a sufficiently high concentration of nucleophilic anion (CN– or CF3 –) which could begin the c...