Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney Injury

• Published in: Analytical chemistry (Washington) Vol. 93; no. 49; pp. 16552 - 16561
• Main Authors: Li, Ao, Luo, Xiangjie, Li, Lingxuan, Chen, Dongxia, Liu, Xing, Yang, Zhaoxuan, Yang, Lijiao, Gao, Jinhao, Lin, Hongyu
• Format: Journal Article
• Language: English
• Published: Washington American Chemical Society 14.12.2021
• Subjects: acute kidney injury; analytical chemistry; Biocompatibility; Biological activity; Biological effects; Chemistry; Differentiation; Drug development; Kidneys; Magnetic resonance imaging; magnetism; Medical imaging; Multiplexing; Nitrogen; oxygen; Probes; Reactive nitrogen species; Reactive oxygen species; Real time; Toxicity

In vivo levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are critical to many physiological and pathological processes. Because of the distinct differences in their biological generation and effects, simultaneously visualizing both of them could help deepen our insights in...