Amidation of Enones via Beckmann Rearrangement

• Published in: Journal of organic chemistry Vol. 89; no. 11; pp. 8201 - 8207
• Main Authors: Verma, Saumya, Singh, Vikram, Jat, Jawahar L., Tiwari, Bhoopendra
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 07.06.2024; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; ALCOHOLS; CINNAMIC ACID-DERIVATIVES; DIRECT TRANSFORMATION; AMINES; BOND FORMATION; ALPHA,BETA-UNSATURATED AMIDES; TANDEM REACTION; ACRYLAMIDES; EFFICIENT; MICHAEL ADDITION

The Beckmann reaction is one of the most atom-economical methods for the preparation of amides from ketones. Unlike ketones, the multiple competing reactivities of enones as well as the requirement of demanding reaction conditions for in situ generation of oximes have severely impacted the applicati...