Scleritis
This book offers a concise but comprehensive overview of scleritis, with up-to-date information on all aspects, including diagnosis and treatment. Fundamental features of the pathogenesis of scleral inflammation are first discussed as a basis for understanding the therapeutic strategies. Detailed de...
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| Main Author | |
|---|---|
| Format | eBook |
| Language | English |
| Published |
Cham
Springer Nature
2017
Springer International Publishing AG Springer International Publishing |
| Edition | 1 |
| Series | Essentials in Ophthalmology |
| Subjects | |
| Online Access | Get full text |
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| Abstract | This book offers a concise but comprehensive overview of scleritis, with up-to-date information on all aspects, including diagnosis and treatment. Fundamental features of the pathogenesis of scleral inflammation are first discussed as a basis for understanding the therapeutic strategies. Detailed descriptions are then provided of clinical manifestations, the complications that can arise during the course of the disease process, and the best way to manage them. An individual chapter is devoted to infectious scleritis and its management, this being an uncommon but serious condition that may result not only in loss of vision but also in loss of the globe itself. The diagnostic approach to and various management options for scleritis are then discussed extensively, with coverage of local and systemic therapy and new strategies, including biologics. Apart from the potential impact on vision, inflammation of the sclera carries a risk of association with systemic diseases, some of which can prove fatal if not promptly recognized and managed. This book is designed to allow ophthalmologists to easily identify the condition and the signs indicative of a more severe problem. It will thereby assist in safe and effective management, and help in preserving vision and life. |
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| AbstractList | This book offers a concise but comprehensive overview of scleritis, with up-to-date information on all aspects, including diagnosis and treatment. Fundamental features of the pathogenesis of scleral inflammation are first discussed as a basis for understanding the therapeutic strategies. Detailed descriptions are then provided of clinical manifestations, the complications that can arise during the course of the disease process, and the best way to manage them. An individual chapter is devoted to infectious scleritis and its management, this being an uncommon but serious condition that may result not only in loss of vision but also in loss of the globe itself. The diagnostic approach to and various management options for scleritis are then discussed extensively, with coverage of local and systemic therapy and new strategies, including biologics. Apart from the potential impact on vision, inflammation of the sclera carries a risk of association with systemic diseases, some of which can prove fatal if not promptly recognized and managed. This book is designed to allow ophthalmologists to easily identify the condition and the signs indicative of a more severe problem. It will thereby assist in safe and effective management, and help in preserving vision and life. |
| Author | Pavesio, Carlos |
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| Copyright | Springer International Publishing AG 2017 |
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| DOI | 10.1007/978-3-319-49915-4 |
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| PublicationDate | 2017 20170311 2017-03-08 |
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| PublicationSeriesTitle | Essentials in Ophthalmology |
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| PublicationYear | 2017 |
| Publisher | Springer Nature Springer International Publishing AG Springer International Publishing |
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| RelatedPersons | Singh, Arun D. |
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| Snippet | This book offers a concise but comprehensive overview of scleritis, with up-to-date information on all aspects, including diagnosis and treatment. Fundamental... |
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| SubjectTerms | Medicine Medicine & Public Health Ophthalmology Sclera Surgery & related medical specialities |
| TableOfContents | Intro -- Preface -- Contents -- Contributors -- 1: Anatomy and Pathogenesis of Scleritis -- Introduction -- Anatomy of the Sclera -- Vasculature -- Markers of Episcleral Vessels -- Cellular Constituents of the Sclera -- Biochemical Makeup of the Human Sclera -- Classification of Scleritis -- Pathogenesis -- Is Scleritis a Localised Ocular Vasculitis? -- Mechanisms of Tissue Destruction in Scleritis -- Pain in Scleritis -- Animal Models of Scleritis -- Future Direction -- References -- 2: Essentials in Ophthalmology, Scleritis: Classification and Clinical Presentations of Scleritis -- Classification -- Clinical Assessment -- Diagnosis of Scleritis -- Types of Scleritis -- Complete Clinical Assessment: Aetiology and Complications -- References -- 3: Associated Systemic Diseases -- Introduction -- Rheumatoid Arthritis -- Granulomatosis with Polyangiitis -- Relapsing Polychondritis -- Systemic Lupus Erythematosus -- Inflammatory Bowel Disease -- Polyarteritis Nodosa -- Seronegative Spondyloarthropathies -- References -- 4: Infectious Scleritis -- Introduction -- Clinical Approach in Infectious Scleritis -- Investigation of the Illness -- Diagnostic Tests -- Tissue Biopsy -- Therapy -- Signs Aiding in Differential Diagnosis -- Bacterial Scleritis -- Gram-Positive Coccus and Gram-Negative Rod Scleritis [5] -- Mycobacterial Scleritis -- Nontuberculous Mycobacterial Scleritis -- Tuberculous Mycobacterial Scleritis -- Spirochetal Scleritis -- Syphilitic Scleritis -- Lyme Scleritis -- Actinomycetic Scleritis -- Nocardiosis -- Fungal Scleritis -- Viral Scleritis -- Parasitic Scleritis -- Acanthamoeba Scleritis -- Toxoplasmosis Scleritis -- Toxocara Scleritis -- References -- 5: Diagnostic Approach to Scleritis -- Introduction -- Episcleritis -- Anterior Scleritis -- Posterior Scleritis -- Etiology of Scleritis -- Noninfectious Scleritis Infectious Scleritis -- Other Causes -- Investigations -- References -- 6: Complications and Their Management -- Introduction -- Keratopathy -- Peripheral Corneal Thinning -- Stromal Keratitis -- Peripheral Ulcerative Keratitis (PUK) -- Uveitis -- Glaucoma -- Angle-Closure Glaucoma -- Open-Angle Glaucoma -- Neovascular Glaucoma -- Cataract -- Orbital Involvement -- References -- 7: Management with Nonsteroidal Anti-inflammatory Agents -- Introduction -- Mechanism of Action -- Pharmacokinetics and Pharmacodynamics -- Efficacy -- Systemic Therapy -- Topical Therapy -- Safety -- Other Important Considerations -- Guidelines for Therapy -- References -- 8: Management with Steroids: Local and Systemic -- Introduction -- Nonsteroidal Anti-inflammatory Drugs (NSAIDs) -- Topical Corticosteroids -- Subconjunctival Corticosteroids -- Administration of Subconjunctival Corticosteroids -- Complications of Subconjunctival Corticosteroids -- Systemic Corticosteroids -- Other Treatment Modalities -- Complications of Corticosteroids -- References -- 9: Management of Scleritis with Immunosuppressive Drugs and Biologic Agents -- Introduction -- Systemic Corticosteroids -- The Antimetabolites: Azathioprine -- The Antimetabolites: Methotrexate -- The Antimetabolites: Mycophenolate Mofetil -- T-Cell Inhibitors: Cyclosporin -- T-Cell Inhibitors: Tacrolimus -- Alkylating Agents: Cyclophosphamide -- Alkylating Agents: Chlorambucil -- The Biologic Immunosuppressive Agents -- TNF-α Inhibitors: Etanercept -- TNF-α Inhibitors: Infliximab -- TNF-α Inhibitors: Adalimumab -- Side Effects of TNF-α Inhibitors -- IL-1 Receptor Antagonist: Anakinra -- IL-2 Receptor Antagonist: Daclizumab -- Anti-CD20 (B-Cell) Antibody: Rituximab -- Long-Term Risk of Malignancy with Immunosuppression and Biologic Therapy -- References -- Index |
| Title | Scleritis |
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