Serotonin1A Receptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia

• Published in: The American journal of psychiatry Vol. 161; no. 4; pp. 739 - 742
• Main Authors: Cruz, Dianne A., Eggan, Stephen M., Azmitia, Efrain C., Lewis, David A.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.04.2004; American Psychiatric Association
• Subjects: Adult and adolescent clinical studies; Axons - metabolism; Biological and medical sciences; Depressive Disorder, Major - metabolism; Female; Humans; Male; Medical sciences; Prefrontal Cortex - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Pyramidal Cells - metabolism; Receptor, Serotonin, 5-HT1A - metabolism; Schizophrenia; Schizophrenia - metabolism; Psychosis; Human; 5-HT1A Serotonine receptor; Immunoreactive form; Central nervous system; Postmortem; Schizophrenia; Prefrontal cortex; Density distribution; Pyramidal neuron; Cell density; Encephalon

OBJECTIVE: Inhibition mediated by -aminobutyric acid at the axon initial segment of pyramidal neurons appears to be altered in the prefrontal cortex in schizophrenia. This study examined the densities and laminar distribution of axon initial segments labeled with an antibody against the serotonin1A...