Molecular Characterization of the Human Neuropeptide Y Y2-Receptor

• Published in: Biochemistry (Easton) Vol. 38; no. 21; pp. 6897 - 6902
• Main Authors: Ingenhoven, Nikolaus, Eckard, Christophe P, Gehlert, Donald R, Beck-Sickinger, Annette G
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 25.05.1999
• Subjects: Amino Acid Sequence; Animals; Blotting, Western; CHO Cells; Cricetinae; Cross-Linking Reagents - metabolism; Humans; Molecular Sequence Data; Neuroblastoma; Neuropeptide Y - chemical synthesis; Neuropeptide Y - metabolism; Photoaffinity Labels - metabolism; Photochemistry; Receptors, Neuropeptide Y - chemistry; Receptors, Neuropeptide Y - genetics; Receptors, Neuropeptide Y - metabolism; Transfection; Tumor Cells, Cultured

Five neuropeptide Y receptors, the Y1-, Y2-, Y4-, Y5- and y6-subtypes, have been cloned, which belong to the rhodopsin-like G-protein-coupled, 7-transmembrane helix-spanning receptors and bind the 36-mer neuromodulator NPY (neuropeptide Y) with nanomolar affinity. In this study, the Y2-receptor subt...