The Role of New Technologies in Defining a Manufacturing Process for PPARα Agonist LY518674

• Published in: Organic process research & development Vol. 13; no. 2; pp. 131 - 143
• Main Authors: Argentine, Mark D, Braden, Timothy M, Czarnik, Jeffrey, Conder, Edward W, Dunlap, Steven E, Fennell, Jared W, LaPack, Mark A, Rothhaar, Roger R, Scherer, R. Brian, Schmid, Christopher R, Vicenzi, Jeffrey T, Wei, Jeffrey G, Werner, John A, Roginski, Robert T
• Format: Journal Article
• Language: English
• Published: American Chemical Society 20.03.2009

The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich experiments, shortened development cycle times, and...