A translocation-competent pore is required for Shigella flexneri to escape from the double membrane vacuole during intercellular spread

• Published in: mBio p. e0167425
• Main Authors: Raab, Julie E., Harju, Tucker B., Toperzer, Jody D., Duncan-Lowey, Jeffrey K., Thomas, Connon I., Darehshouri, Anza, Goldberg, Marcia B., Russo, Brian C.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 11.08.2025
• Subjects: Host-Microbial Interactions; Research Article; double membrane vacuole; type 3 secretion; intercellular spread; translocation; IpaC; Shigella

The type 3 secretion system (T3SS) is required for virulence inmany bacterial pathogens that infect humans. The T3SS forms a pore through which virulence proteins are delivered into host cells, enabling bacterial infection. Our work investigates the Shigella translocon pore protein IpaC, which is es...