The Synthesis of a Dopamine D2 Partial Agonist for the Treatment of Schizophrenia

• Published in: Organic process research & development Vol. 13; no. 3; pp. 555 - 566
• Main Authors: Magano, Javier, Acciacca, Alison, Akin, Anne, Collman, Benjamin M, Conway, Brian, Waldo, Michael, Chen, Michael H, Mennen, Kenneth E
• Format: Journal Article
• Language: English
• Published: American Chemical Society 15.05.2009

The synthesis of the phosphoric acid salt of dopamine D2 partial agonist 2-{4-[4-(7-fluoro-naphthalen-1-yl)-piperazin-1-yl]-butoxy}-5,6,7,9-tetrahydro-1,7,9-triaza-benzocyclohepten-8-one (1) is reported. The most prominent feature of the molecule is a seven-membered ring urea functionality that has...