Solution to the C3–Arylation of Indazoles: Development of a Scalable Method

• Published in: Organic letters Vol. 18; no. 13; pp. 3218 - 3221
• Main Authors: Basu, Kallol, Poirier, Marc, Ruck, Rebecca T
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.07.2016

3-(Hetero)­arylindazoles are important motifs in several biologically active compounds. Mild and flexible palladium-mediated Negishi reaction conditions are reported for the introduction of (hetero)­aryl moieties at the 3-position of N(2)-SEM-protected indazoles in high yields. The requisite Zn-spec...