Mechanistic Investigation of the Iron-Catalyzed Azidation of Alkyl C(sp 3)–H Bonds with Zhdankin’s λ3‑Azidoiodane

• Published in: Journal of the American Chemical Society Vol. 143; no. 39; pp. 16184 - 16196
• Main Authors: Day, Craig S, Fawcett, Alexander, Chatterjee, Ruchira, Hartwig, John F
• Format: Journal Article
• Language: English
• Published: American Chemical Society 06.10.2021

An in-depth study of the mechanism of the azidation of C­(sp 3)–H bonds with Zhdankin’s λ3-azidoiodane reagent catalyzed by iron­(II)­(pybox) complexes is reported. Previously, it was shown that tertiary and benzylic C­(sp 3)–H bonds of a range of complex molecules underwent highly site-selective az...