TiCl4‑Catalyzed Hydroboration of Ketones with Ammonia Borane

• Published in: Journal of organic chemistry Vol. 87; no. 19; pp. 13259 - 13269
• Main Authors: Ramachandran, P. Veeraraghavan, Alawaed, Abdulkhaliq A., Hamann, Henry J.
• Format: Journal Article
• Language: English
• Published: American Chemical Society 07.10.2022

Investigation of a variety of Lewis acids for the hydroboration-hydrolysis (reduction) of ketones with amine-boranes has revealed that catalytic (10 mol %) titanium tetrachloride (TiCl4) in diethyl ether at room temperature immensely accelerates the reaction of ammonia borane. The product alcohols a...