Ability of curcuminoid compared to diclofenac sodium in reducing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes of patients with osteoarthritis

• Published in: Acta medica Indonesiana Vol. 44; no. 2; p. 105
• Main Authors: Kertia, Nyoman, Asdie, Ahmad H, Rochmah, Wasilah, Marsetyawan
• Format: Journal Article
• Language: English
• Published: Indonesia 01.04.2012
• Subjects: Aged; Curcuma; Cyclooxygenase 2 - drug effects; Cyclooxygenase 2 - secretion; Cyclooxygenase Inhibitors - pharmacology; Cyclooxygenase Inhibitors - therapeutic use; Diclofenac - pharmacology; Diclofenac - therapeutic use; Female; Humans; Male; Middle Aged; Monocytes - drug effects; Monocytes - enzymology; Osteoarthritis, Knee - drug therapy; Osteoarthritis, Knee - enzymology; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rhizome; Single-Blind Method; Synovial Fluid - drug effects; Synovial Fluid - enzymology
• ISSN: 0125-9326

to assess the ability of curcuminoid from Curcuma domestica Val in reducing the cycloxygenase-2 secretion by synovial fluid's monocytes compared to diclofenac sodium in patients with osteoarthritis. this was a prospective randomized open end blinded evaluation (PROBE) study. The subjects were patients with knee osteoarthritis who were divided randomly into two groups, the first group received 30 mg 3 times daily of curcuminoid and the second group received 25 mg 3 times daily of diclofenac sodium. The joints aspiration was done and the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes was evaluated by scoring method before and after 4 weeks of treatments. a total of 80 patients with knee osteoarthritis were enrolled. In curcuminoid group the average scores were 1.84±0.37 and 1.15±0.28 respectively (p<0.001). In diclofenac group the average scores were 1.79±0.38 and 1.12±0.27 respectively (p<0.001). In curcuminoid group the decreasing score of cycloxygenase-2 secretion was 0.70±0.51 while in diclofenac group was 0.67±0.45. There was no significant difference in decreasing the score of cycloxygenase enzyme secretion between both treatment groups (p=0.89). the ability of curcuminoid from Curcuma domestica Val. rhizome extract was not significantly different compared to diclofenac sodium in suppressing the secretion of cycloxygenase-2 enzyme by synovial fluid's monocytes.