Host-microbe interactions
Host-Microbe Interactions, the latest volume in the Progress in Molecular Biology series, provides a forum for the discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their respective fields, along with abundant references. This volume...
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| Main Authors | , |
|---|---|
| Format | eBook Book |
| Language | English |
| Published |
Amsterdam
Academic Press, an imprint of Elsevier
2016
Elsevier Science & Technology Academic Press |
| Edition | 1 |
| Series | Progress in molecular biology and translational science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Host-Microbe Interactions, the latest volume in the Progress in Molecular Biology series, provides a forum for the discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their respective fields, along with abundant references. This volume is dedicated to the subject of host-microbe interactions.
Provides the latest research on host-microbe interactions, including new discoveries, approaches, and ideasContains contributions from leading authorities on topics relating to molecular biologyInforms and updates on all the latest developments in the field |
|---|---|
| AbstractList | Host-Microbe Interactions, the latest volume in the Progress in Molecular Biology series, provides a forum for the discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their respective fields, along with abundant references. This volume is dedicated to the subject of host-microbe interactions.
Provides the latest research on host-microbe interactions, including new discoveries, approaches, and ideasContains contributions from leading authorities on topics relating to molecular biologyInforms and updates on all the latest developments in the field |
| Author | San Francisco, Michael San Francisco, Brian |
| Author_xml | – sequence: 1 fullname: San Francisco, Michael – sequence: 2 fullname: San Francisco, Brian |
| BackLink | https://cir.nii.ac.jp/crid/1130282272181846272$$DView record in CiNii |
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| EISBN | 0128096179 9780128096178 |
| Edition | 1 |
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| Notes | Includes bibliographical references and index |
| OCLC | 956397214 |
| PQID | EBC4624957 |
| PageCount | 346 |
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| PublicationDate | 2016 2016-08-01 |
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| PublicationPlace | Amsterdam |
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| PublicationSeriesTitle | Progress in molecular biology and translational science |
| PublicationYear | 2016 |
| Publisher | Academic Press, an imprint of Elsevier Elsevier Science & Technology Academic Press |
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| Snippet | Host-Microbe Interactions, the latest volume in the Progress in Molecular Biology series, provides a forum for the discussion of new discoveries, approaches,... |
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| SubjectTerms | Host-parasite relationships Molecular biology Plant-pathogen relationships |
| TableOfContents | 2.2 Macrophages and Pathogenic Biofilms -- 2.3 Adaptive Immune Response and Pathogenic Biofilms -- 3 Interactions of Commensal Biofilms With the Immune System -- 3.1 Overview of Probiotic Biofilms -- 3.2 Neutrophils, Monocytes/Macrophages, and Probiotic Biofilms -- 3.2.1 Neutrophils -- 3.2.2 Monocytes -- 3.2.3 Macrophages -- 3.3 Probiotic Biofilms and Gut Immunity -- 3.4 Probiotic Biofilms and Vaginal Immunity -- 3.5 Probiotic Biofilms and Skin Immunity -- Acknowledgments -- References -- Chapter Eight - Viral interactions with components of the splicing machinery -- Abstract -- 1 Introduction -- 2 The Spliceosome -- 3 The Splicing Reaction -- 4 Viruses and Alternative Splicing -- 5 Retroviruses -- 5.1 Suboptimal Splicing -- 5.2 Nuclear Export -- 6 Herpesviruses -- 6.1 Splicing Inhibition -- 6.2 Nuclear Export -- 6.3 Splicing Enhancement of Viral RNA -- 7 Influenza Viruses -- 7.1 Splicing Enhancement -- 7.2 Splicing Downregulation -- 7.3 Nuclear Export -- 8 Concluding Remarks -- Acknowledgments -- References -- Chapter Nine - Insights From Genomics Into Spatial and Temporal Variation in Batrachochytrium dendrobatidis -- Abstract -- 1 Insights From Genomics Into Bd Variation -- 1.1 A Molecular Toolkit for Bd -- 1.2 Phylogenetic and Geographic Variation -- 1.3 Structural and Functional Genomic Variation -- 2 New Frontiers in Bd Genomics -- 2.1 An Evolving Genomic Toolkit -- 2.2 Applying Genomics to Understand Temporal Variation in Bd -- 2.3 Applying Genomics to Understand Spatial Variation in Bd -- 2.4 Applying Genomics to Understand Functional Variation in Bd -- 3 Conclusions -- References -- Chapter Ten - Translational Activities to Enable NTD Vaccines -- Abstract -- 1 Introduction -- 1.1 Parasitic NTDs -- 1.1.1 Soil-Transmitted Helminths -- 1.1.2 Schistosomiasis -- 1.1.3 Leishmaniasis -- 1.1.4 River Blindness -- 1.1.5 Chagas Disease Cover -- Title page -- Copyright Page -- Contents -- Contributors -- Preface -- Chapter One - Competition for Manganese at the Host-Pathogen Interface -- Abstract -- 1 Introduction -- 2 Imposition of Manganese Starvation by the Host -- 3 Bacterial Adaptation to Manganese Limitation -- 4 Impact of Manganese Limitation on Invading Microbes -- 5 Conclusions and Broader Impacts -- References -- Chapter Two - Microbial Virulence and Interactions With Metals -- Abstract -- 1 Iron -- 1.1 Sequestering of Iron by Bacteria -- 2 Copper -- 2.1 Plasmid-Borne Resistance -- 2.2 Copper-Binding Siderophores -- 3 Manganese -- 4 Zinc -- References -- Chapter Three - Virulence Program of a Bacterial Plant Pathogen: The Dickeya Model -- Abstract -- 1 Introduction -- 2 Dickeya Ecology -- 3 The Virulence Determinants of D. Dadantii -- 3.1 The Effectors of Type-I and Type-II Secretion Systems -- 3.2 The Hrp Type-III Secretion System and Its Substrates -- 3.3 The Siderophores and Iron Metabolism -- 4 Plant-Pathogen Interaction Process -- 4.1 Adhesion to Plant Surface and Entry Into Apoplast -- 4.2 Role of Multiple Efflux Pumps for Surviving in the Plant Apoplast -- 4.3 Adaptation to the Acidic Environment of Apoplast and to Plant Antimicrobial Peptides -- 4.4 Adaptation to Anaerobiosis Conditions in Plant Tissue -- 4.5 Adaptation to Reactive Oxygen Species Produced by Plant in Response to Infection -- 4.6 Adaptation to Osmotic Stress Resulting From Plant Cell Lysis -- 5 Regulatory Mechanisms Coordinating the Virulence Program -- 5.1 Regulatory Network Coordinating Multiple Virulence Factor Expression -- 5.2 NAPs and Chromosome Dynamics -- 6 Concluding Remarks -- References -- Chapter Four - Metabolism and Virulence Strategies in Dickeya-Host Interactions -- Abstract -- 1 Introduction -- 2 The Dickeya Virulence Strategy -- 2.1 Plant Colonization and the Infectious Phases 2.2 Pectate Lyases and Plant Cell Wall Degradation -- 3 The Dickeya Catabolic Capacities -- 3.1 What Information From the Genome? -- 3.2 The Transcriptomic Approaches -- 3.3 Contribution of Metabolomics -- 4 The Major Carbon Sources Assimilated by Bacteria in Plant Tissues -- 4.1 Utilization of the Plant Soluble Sugars -- 4.2 Utilization of Sugars Derived From Pectic Polysaccharides -- 5 The Regulators Coordinating Virulence and Metabolism -- 5.1 The Pectin Sensor KdgR -- 5.2 The cAMP Receptor Protein (Crp) for Preferential Sugar Utilization -- 5.3 The GacA/GacS Two-Component System and Rsm Posttranscriptional Regulation -- 5.4 Other Regulatory Systems -- 6 Concluding Remarks -- Acknowledgments -- References -- Chapter Five - Multidrug Efflux Pumps in the Genus Erwinia: Physiology and Regulation of Efflux Pump Gene Expression -- Abstract -- 1 Introduction -- 1.1 Plant-Pathogen Interaction: An Overview -- 2 Bacterial efflux pumps -- 2.1 Types -- 2.2 Occurrence -- 3 Efflux pumps in Erwinia -- 3.1 RND Efflux Pumps -- 3.1.1 Acr (Acriflavine) Efflux System -- 3.1.2 MdtABCD and MdtUVW Efflux Pumps -- 3.2 MFS Efflux Pumps -- 3.2.1 EmrAB Efflux Pump -- 3.2.2 YceE Efflux Pump -- 3.2.3 Sugar Efflux Pumps -- 3.3 ABC Transporters -- 3.3.1 YbiT Efflux Pump -- 3.4 MATE Efflux Pump -- 3.4.1 NorM Efflux Pump -- 4 Mechanism of regulation of efflux pump gene expression -- 4.1 Regulation by Local Regulators -- 4.2 Regulation by Global Response Regulators -- 4.3 Regulation by Two-Component System -- 4.3.1 BaeSR Two-Component Regulatory System -- 5 Future directions -- Acknowledgements -- References -- Chapter Six - In Vitro Analysis of Pseudomonas aeruginosa Virulence Using Conditions That Mimic the Environment at Specific Infection Sites -- Abstract -- 1 Introduction -- 1.1 Rationale for Using Media That Mimic Host Infection Sites -- 1.2 Pseudomonas aeruginosa 1.1.6 Other NTDs -- 2 Current Landscape of Vaccines for NTDs -- 2.1 Why the Lack of Vaccines to NTDs? -- 2.1.1 Financing -- 2.1.2 Identification of a Target Population -- 2.1.3 Achieving Sterilizing Immunity -- 2.1.4 Defining a Target Vaccine Product Profile -- 3 Developmental Process for NTD Vaccines -- 3.1 Type of Vaccines -- 3.2 Choice of Expression System -- 3.2.1 Bacterial Expression -- 3.2.2 Yeast Expression -- 3.2.3 Cell Culture Expression -- 3.2.4 Plant Cell Expression -- 3.3 Scale-Up of Expression -- 3.3.1 Primary Expression Screen -- 3.3.2 Development of Seed Stock -- 3.3.3 Scale-Up and Fermentation -- 3.4 Large-Scale Purification -- 3.5 Characterization of Antigens -- 3.5.1 Biophysical Characterization -- 3.5.2 Lyophilization and Excipient Screening -- 4 Vaccine Embodiment-Going From an Antigen to a Deployable Vaccine -- 4.1 Adjuvants -- 4.2 Dosing and Administration -- 5 Concluding Remarks -- Acknowledgments -- References -- Index -- Colour Plate -- Back cover 2 Virulence Factors Produced by P. aeruginosa -- 2.1 Cell-Associated Virulence Factors -- 2.2 Extracellular Virulence Factors -- 3 Specific Virulence Factors Affected By Host Conditions -- 3.1 Alginate -- 3.2 Iron Chelation -- 3.3 ExoU Cytotoxin -- 3.4 Quorum Sensing -- 4 Synthetic Media That Mimic Specific Host Environments -- 4.1 Media That Mimic the CF Lung Environment for Analysis of Gene Expression -- 4.1.1 Cystic Fibrosis -- 4.1.2 Chronic P. aeruginosa Lung Infection in CF -- 4.1.3 CF Respiratory Mucus Medium -- 4.1.4 Mucopurulent Material Medium -- 4.1.5 Ten Percent CF Sputum Medium -- 4.1.6 Synthetic CF Sputum Medium -- 4.2 Media to Analyze Biofilm Formation by CF Lung Isolates -- 4.2.1 Biofilms -- 4.2.2 Use of Mucin as a Substrate for Biofilm Formation -- 4.2.3 Artificial Sputum Medium -- 4.2.4 Modified Artificial Sputum Medium -- 4.2.5 Use of Artificial Sputum Medium to Examine Formation of Biofilm-Like Structures -- 4.3 Media for Analysis of P. aeruginosa Virulence in Wound and Systemic Infections -- 4.3.1 Acute and Chronic Wounds -- 4.3.2 Effect of Individual Blood Components on P. aeruginosa Biofilm Formation -- 4.3.3 Effect of Blood Components on P. aeruginosa Gene Expression -- 4.3.4 Bacteremia and Sepsis -- 4.3.5 Effect of Transfer to Whole Blood on Bacterial Gene Expression -- 4.3.6 Use of Whole Blood in an Ex Vivo Culture System -- 5 Conclusions -- References -- Chapter Seven - Host Responses to Biofilm -- Abstract -- 1 Host Immune Responses to Biofilm Constituents -- 1.1 The Immune Response to Exopolysaccharides -- 1.2 The Immune Response to Extracellular DNA -- 1.3 The Immune Response to Exoproteins in the Biofilm -- 1.4 The Immune Challenge of Outer Membrane Vesicles -- 1.5 Host Responses to Biofilm-Associated Small Molecules -- 2 Pathogenic Biofilms and Host Cells -- 2.1 Neutrophils and Pathogenic Biofilms |
| Title | Host-microbe interactions |
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| Volume | v.Volume 142 |
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