Model of Drug-Loaded Fluorocarbon-Based Micelles Studied by Electron-Spin Induced 19F Relaxation NMR and Molecular Dynamics Simulation

• Published in: Langmuir Vol. 24; no. 3; pp. 692 - 700
• Main Authors: Mathias, Errol V, Liu, Xiangli, Franco, Osmundo, Khan, Imran, Ba, Yong, Kornfield, Julia A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 05.02.2008
• Subjects: Chemistry; Colloidal gels. Colloidal sols; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Micelles. Thin films; Surface physical chemistry; Water; Drug; Molecular structure; Spin; Molecular dynamics; Micelle; Polymer; NMR spectrometry; Fluorocarbon; Hydrophobicity; Colloidal gel; Ethylene oxide polymer; Relaxation; Halogenated hydrocarbon; Simulation; Spin label; Sol gel process; Affinity; Models; Hydrogel; Electrons

R f-IPDU-PEGs belong to a class of fluoroalkyl-ended poly(ethylene glycol) polymers (R f-PEGs), where the IPDU (isophorone diurethane) functions as a linker to connect each end of the PEG chain to a fluoroalkyl group. The R f-IPDU-PEGs form hydrogels in water with favorable sol−gel coexistence prope...