In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy

• Published in: JAMA psychiatry (Chicago, Ill.) Vol. 71; no. 1; p. 19
• Main Authors: Du, Fei, Cooper, Alissa J, Thida, Thida, Sehovic, Selma, Lukas, Scott E, Cohen, Bruce M, Zhang, Xiaoliang, Ongür, Dost
• Format: Journal Article
• Language: English
• Published: United States 01.01.2014
• Subjects: Adenosine Triphosphate - analysis; Adult; Brain - metabolism; Brain - physiopathology; Brain Chemistry; Case-Control Studies; Creatine Kinase - metabolism; Cross-Sectional Studies; Energy Metabolism - physiology; Female; Frontal Lobe - metabolism; Frontal Lobe - physiopathology; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy - methods; Male; Phosphocreatine - analysis; Phosphorus Isotopes - metabolism; Schizophrenia - metabolism; Schizophrenia - physiopathology

Abnormalities in neural activity and cerebral bioenergetics have been observed in schizophrenia (SZ). Further defining energy metabolism anomalies would provide crucial information about molecular mechanisms underlying SZ and may be valuable for developing novel treatment strategies. To investigate...