Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling

• Published in: mBio Vol. 12; no. 2
• Main Authors: Kastan, Jonathan P, Tremblay, Martine W, Brown, Michael C, Trimarco, Joseph D, Dobrikova, Elena Y, Dobrikov, Mikhail I, Gromeier, Matthias
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 13.04.2021
• Subjects: Research Article; type I interferon; Jak/Stat signaling; 2A protease; m6A modification; enterovirus; innate immunity; type III interferon; YTHDF proteins; poliovirus; interferon stimulated gene

Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation. Here, we report that EV 2A proteases cleave all three members of the YTHDF protein family, cytosolic N6-methyladenosine (m6A) “readers” that regulate target mRNA fate. YTHDF protein cleavage o...