BiG-MAP: an Automated Pipeline To Profile Metabolic Gene Cluster Abundance and Expression in Microbiomes

• Published in: mSystems Vol. 6; no. 5
• Main Authors: Pascal Andreu, Victória, Augustijn, Hannah E., van den Berg, Koen, van der Hooft, Justin J. J., Fischbach, Michael A., Medema, Marnix H.
• Format: Journal Article
• Language: English
• Published: 1752 N St., N.W., Washington, DC American Society for Microbiology 01.10.2021
• Subjects: Computational Biology; Methods and Protocols; metabolic gene cluster; metatranscriptomics; metabolomics; metagenomics; biosynthesis; specialized metabolism; microbiome; microbiome-associated phenotype

Microbial gene clusters encoding the biosynthesis of primary and secondary metabolites play key roles in shaping microbial ecosystems and driving microbiome-associated phenotypes. Although effective approaches exist to evaluate the metabolic potential of such bacteria through identification of these...