Chemical and Biological Investigation of the Fungus Pulveroboletus r avenelii

Two new compounds, pulveraven A (1) and pulveraven B (2), as well as vulpinic acid (3) and its previously unreported polymorph were isolated from the fruiting body of Pulveroboletus ravenelii. The structures were determined using a combination of NMR, MS, IR, optical rotation, molecular modeling, an...

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Published inJournal of natural products (Washington, D.C.) Vol. 66; no. 1; pp. 103 - 107
Main Authors Duncan, Christine J. G, Cuendet, Muriel, Fronczek, Frank R, Pezzuto, John M, Mehta, Rajendra G, Hamann, Mark T, Ross, Samir A
Format Journal Article
LanguageEnglish
Published American Chemical Society 24.01.2003
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Summary:Two new compounds, pulveraven A (1) and pulveraven B (2), as well as vulpinic acid (3) and its previously unreported polymorph were isolated from the fruiting body of Pulveroboletus ravenelii. The structures were determined using a combination of NMR, MS, IR, optical rotation, molecular modeling, and X-ray analysis. The isolates were evaluated for antimicrobial activity as well as their potential to inhibit cyclooxygenase (COX) activity and carcinogen-induced preneoplastic lesion formation with mouse mammary organ culture (MMOC).
ISSN:0163-3864
1520-6025
DOI:10.1021/np0203990