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Probing the Mechanism of Receptor Activity–Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists
Booe, Jason M., Warner, Margaret L., Roehrkasse, Amanda M., Hay, Debbie L., Pioszak, Augen A.
Published in Molecular pharmacology (01.04.2018)
Published in Molecular pharmacology (01.04.2018)
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Receptor activity‐modifying protein‐dependent effects of mutations in the calcitonin receptor‐like receptor: implications for adrenomedullin and calcitonin gene‐related peptide pharmacology
Watkins, H A, Walker, C S, Ly, K N, Bailey, R J, Barwell, J, Poyner, D R, Hay, D L
Published in British journal of pharmacology (01.02.2014)
Published in British journal of pharmacology (01.02.2014)
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Differential expression of components of the CGRP-receptor family in human coronary and human middle meningeal arteries: functional implications
de Vries, Tessa, Schutter, Dennis, van den Bogaerdt, Antoon, Vincent, Arnaud, Dammers, Ruben, Danser, A. H. Jan, MaassenVanDenBrink, Antoinette
Published in Journal of headache and pain (10.10.2024)
Published in Journal of headache and pain (10.10.2024)
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Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin 2 G protein-coupled receptor
Babin, Katie M, Karim, Jordan A, Gordon, Peyton H, Lennon, James, Dickson, Alex, Pioszak, Augen A
Published in The Journal of biological chemistry (01.06.2023)
Published in The Journal of biological chemistry (01.06.2023)
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Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor
Booe, Jason M., Walker, Christopher S., Barwell, James, Kuteyi, Gabriel, Simms, John, Jamaluddin, Muhammad A., Warner, Margaret L., Bill, Roslyn M., Harris, Paul W., Brimble, Margaret A., Poyner, David R., Hay, Debbie L., Pioszak, Augen A.
Published in Molecular cell (18.06.2015)
Published in Molecular cell (18.06.2015)
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Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS
Lee, Sang-Min, Hay, Debbie L, Pioszak, Augen A
Published in The Journal of biological chemistry (15.04.2016)
Published in The Journal of biological chemistry (15.04.2016)
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Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction
Qiao, Xi, Wang, Lihua, Wang, Yanhong, Zhao, Ning, Zhang, Ruijing, Han, Weixia, Peng, Zhiqiang
Published in Nephrology (Carlton, Vic.) (01.11.2015)
Published in Nephrology (Carlton, Vic.) (01.11.2015)
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Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
Watkins, Harriet A., Chakravarthy, Madhuri, Abhayawardana, Rekhati S., Gingell, Joseph J., Garelja, Michael, Pardamwar, Meenakshi, McElhinney, James M.W.R., Lathbridge, Alex, Constantine, Arran, Harris, Paul W.R., Yuen, Tsz-Ying, Brimble, Margaret A., Barwell, James, Poyner, David R., Woolley, Michael J., Conner, Alex C., Pioszak, Augen A., Reynolds, Christopher A., Hay, Debbie L.
Published in The Journal of biological chemistry (27.05.2016)
Published in The Journal of biological chemistry (27.05.2016)
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Intermedin Stabilized Endothelial Barrier Function and Attenuated Ventilator-induced Lung Injury in Mice
Müller-Redetzky, Holger Christian, Kummer, Wolfgang, Pfeil, Uwe, Hellwig, Katharina, Will, Daniel, Paddenberg, Renate, Tabeling, Christoph, Hippenstiel, Stefan, Suttorp, Norbert, Witzenrath, Martin
Published in PloS one (01.05.2012)
Published in PloS one (01.05.2012)
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Adrenomedullin 2 and 5 activate the calcitonin receptor-like receptor (clr) – Receptor activity-modifying protein 3 (ramp3) receptor complex in Xenopus tropicalis
Ogoshi, Maho, Takahashi, Mikoto, Aoyagi, Kota, Ukena, Kazuyoshi, Aizawa, Sayaka, Takeuchi, Hideaki, Takahashi, Sumio, Takeuchi, Sakae
Published in General and comparative endocrinology (15.05.2021)
Published in General and comparative endocrinology (15.05.2021)
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Intermedin in Paraventricular Nucleus Attenuates Sympathetic Activity and Blood Pressure via Nitric Oxide in Hypertensive Rats
Zhou, Ye-Bo, Sun, Hai-Jian, Chen, Dan, Liu, Tong-Yan, Han, Ying, Wang, Jue-Jin, Tang, Chao-Shu, Kang, Yu-Ming, Zhu, Guo-Qing
Published in Hypertension (Dallas, Tex. 1979) (01.02.2014)
Published in Hypertension (Dallas, Tex. 1979) (01.02.2014)
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Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice
Pawlak, J.B., Wetzel-Strong, S.E., Dunn, M.K., Caron, K.M.
Published in Peptides (New York, N.Y. : 1980) (01.02.2017)
Published in Peptides (New York, N.Y. : 1980) (01.02.2017)
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Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus
Lutz, Thomas A., Coester, Bernd, Whiting, Lynda, Dunn-Meynell, Ambrose A., Boyle, Christina N., Bouret, Sebastien G., Levin, Barry E., Le Foll, Christelle
Published in Diabetes (New York, N.Y.) (01.05.2018)
Published in Diabetes (New York, N.Y.) (01.05.2018)
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RAMP1 and RAMP3 Differentially Control Amylin’s Effects on Food Intake, Glucose and Energy Balance in Male and Female Mice
Coester, Bernd, Pence, Sydney W., Arrigoni, Soraya, Boyle, Christina N., Le Foll, Christelle, Lutz, Thomas A.
Published in Neuroscience (01.11.2020)
Published in Neuroscience (01.11.2020)
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Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target
Pacharne, Suruchi, Livesey, Matthew, Kadmiel, Mahita, Wang, Ning, Caron, Kathleen M., Richards, Gareth O., Skerry, Tim M.
Published in Frontiers in endocrinology (Lausanne) (12.01.2022)
Published in Frontiers in endocrinology (Lausanne) (12.01.2022)
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Shared and separate functions of the RAMP-based adrenomedullin receptors
Kuwasako, Kenji, Kitamura, Kazuo, Nagata, Sayaka, Hikosaka, Tomomi, Takei, Yoshio, Kato, Johji
Published in Peptides (New York, N.Y. : 1980) (01.07.2011)
Published in Peptides (New York, N.Y. : 1980) (01.07.2011)
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Expression profile of adrenomedullin and its specific receptors in liver tissues from patients with hepatocellular carcinoma and in tumorigenic cell line-secreted extracellular vesicles
Cabiati, Manuela, Gaggini, Melania, De Simone, Paolo, Salvadori, Costanza, Del Turco, Serena, Caselli, Chiara, Cecchettini, Antonella, Del Ry, Silvia
Published in Pathology, research and practice (01.03.2023)
Published in Pathology, research and practice (01.03.2023)
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Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase
Sakurai, Takayuki, Kamiyoshi, Akiko, Takei, Norio, Watanabe, Satoshi, Sato, Masahiro, Shindo, Takayuki
Published in Scientific reports (09.07.2019)
Published in Scientific reports (09.07.2019)
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Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3
Carvas, Alexandra Oliveira, Leuthardt, Andrea, Kulka, Patricia, Lommi, Greta, Hassan, Shad, Coester, Bernd, Lundh, Sofia, Pers, Tune, Secher, Anna, Raun, Kirsten, Lutz, Thomas A., Le Foll, Christelle
Published in EBioMedicine (01.08.2025)
Published in EBioMedicine (01.08.2025)
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