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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro‑2H‑pyran-4-yl)-1,3-dihydro‑2H‑imidazo[4,5‑c]quinolin-2-one)

by Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)

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Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (14.07.2016)

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Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (23.04.2015)

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Two Novel 1,2,4,5-Tetrazines that Participate in Inverse Electron Demand Diels−Alder Reactions with an Unexpected Regioselectivity

Two Novel 1,2,4,5-Tetrazines that Participate in Inverse Electron Demand Diels−Alder Reactions with an Unexpected Regioselectivity

by Hamasaki, Akiyuki, Ducray, Richard, Boger, Dale L
Published in Journal of organic chemistry (06.01.2006)

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Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Investigation of (E)-344-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sebastien L., Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamontt, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Remy, Norman, Richard A., Peru, Aurelien, Pink, Jennifer H., Ple, Patrick A., Roberts, Bryan, Scott, James S.
Published in Journal of medicinal chemistry (23.04.2015)

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Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)

Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2‑(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor‑1 Receptor (IGF-1R)

by Degorce, Sébastien L, Boyd, Scott, Curwen, Jon O, Ducray, Richard, Halsall, Christopher T, Jones, Clifford D, Lach, Franck, Lenz, Eva M, Pass, Martin, Pass, Sarah, Trigwell, Catherine
Published in Journal of medicinal chemistry (26.05.2016)

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Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

by Ducray, Richard, Jones, Clifford D., Jung, Frederic H., Simpson, Iain, Curwen, Jon, Pass, Martin
Published in Bioorganic & medicinal chemistry letters (15.08.2011)

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Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase

by Ducray, Richard, Simpson, Iain, Jung, Frederic H., Nissink, J. Willem M., Kenny, Peter W., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin
Published in Bioorganic & medicinal chemistry letters (15.08.2011)

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Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

Correction to Investigation of (E)‑3-[4-(2-Oxo-3-aryl-chromen-4-yl)oxyphenyl]acrylic Acids as Oral Selective Estrogen Receptor Down-Regulators

by Degorce, Sébastien L, Bailey, Andrew, Callis, Rowena, De Savi, Chris, Ducray, Richard, Lamont, Gillian, MacFaul, Philip, Maudet, Mickael, Martin, Scott, Morgentin, Rémy, Norman, Richard A, Peru, Aurélien, Pink, Jennifer H, Plé, Patrick A, Roberts, Bryan, Scott, James S
Published in Journal of medicinal chemistry (14.04.2016)

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Devic’s syndrome-like phenotype associated with thymoma and anti-CV2/CRMP5 antibodies

Devic’s syndrome-like phenotype associated with thymoma and anti-CV2/CRMP5 antibodies

by Ducray, François, Roos-Weil, Richard, Garcia, Pierre Yves, Slesari, Juliana, Heinzlef, Olivier, Chatelain, Denis, Toussaint, Philippe, Roullet, Etienne, Honnorat, Jérôme
Published in Journal of neurology, neurosurgery and psychiatry (01.03.2007)

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A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2- a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5- a]pyridines

A versatile route to 3-(pyrimidin-4-yl)-imidazo[1,2- a]pyridines and 3-(pyrimidin-4-yl)-pyrazolo[1,5- a]pyridines

by Ducray, Richard, Boutron, Pascal, Didelot, Myriam, Germain, Hervé, Lach, Franck, Lamorlette, Maryannick, Legriffon, Antoine, Maudet, Mickael, Ménard, Morgan, Pasquet, Georges, Renaud, Fabrice, Simpson, Iain, Young, Gail L.
Published in Tetrahedron letters (08.09.2010)

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The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one)

by Pike, Kurt G, Barlaam, Bernard, Cadogan, Elaine, Campbell, Andrew, Chen, Yingxue, Colclough, Nicola, Davies, Nichola L, de-Almeida, Camila, Degorce, Sebastien L, Didelot, Myriam, Dishington, Allan, Ducray, Richard, Durant, Stephen T, Hassall, Lorraine A, Holmes, Jane, Hughes, Gareth D, MacFaul, Philip A, Mulholland, Keith R, McGuire, Thomas M, Ouvry, Gilles, Pass, Martin, Robb, Graeme, Stratton, Natalie, Wang, Zhenhua, Wilson, Joanne, Zhai, Baochang, Zhao, Kang, Al-Huniti, Nidal
Published in Journal of medicinal chemistry (10.05.2018)

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Journal Article

Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

Correction to Discovery of Novel 3‑Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase

by Degorce, Sébastien L, Barlaam, Bernard, Cadogan, Elaine, Dishington, Allan, Ducray, Richard, Glossop, Steven C, Hassall, Lorraine A, Lach, Franck, Lau, Alan, McGuire, Thomas M, Nowak, Thorsten, Ouvry, Gilles, Pike, Kurt G, Thomason, Andrew G
Published in Journal of medicinal chemistry (26.07.2018)

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A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

A new series of neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

by Barlaam, Bernard, Ballard, Peter, Bradbury, Robert H., Ducray, Richard, Germain, Hervé, Hickinson, D. Mark, Hudson, Kevin, Kettle, Jason G., Klinowska, Teresa, Magnien, Françoise, Ogilvie, Donald J., Olivier, Annie, Pearson, Stuart E., Scott, James S., Suleman, Abid, Trigwell, Cath B., Vautier, Michel, Whittaker, Robin D., Wood, Robin
Published in Bioorganic & medicinal chemistry (15.01.2008)

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Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors

by DUCRAY, Richard, BALLARD, Peter, BARLAAM, Bernard C, HICKINSON, Mark D, KETTLE, Jason G, OGILVIE, Donald J, TRIGWELL, Catherine B
Published in Bioorganic & medicinal chemistry (01.02.2008)

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Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

by Bardelle, Catherine, Barlaam, Bernard, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Ducray, Richard, Green, Isabelle, Brempt, Christine Lambert-van der, Olivier, Annie, Read, Jon
Published in Bioorganic & medicinal chemistry letters (01.11.2010)

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Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

by Barlaam, Bernard, Ducray, Richard, Brempt, Christine Lambert-van der, Plé, Patrick, Bardelle, Catherine, Brooks, Nigel, Coleman, Tanya, Cross, Darren, Kettle, Jason G., Read, Jon
Published in Bioorganic & medicinal chemistry letters (15.04.2011)

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Total Synthesis of (±)-FR66979

Total Synthesis of (±)-FR66979

by Ducray, Richard, Ciufolini, Marco A.
Published in Angewandte Chemie (International ed.) (16.12.2002)

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Tris(trifluoromethanesulfonyl)methide (“Triflide”) Anion: Convenient Preparation, X-ray Crystal Structures, and Exceptional Catalytic Activity as a Counterion with Ytterbium(III) and Scandium(III)

Tris(trifluoromethanesulfonyl)methide (“Triflide”) Anion: Convenient Preparation, X-ray Crystal Structures, and Exceptional Catalytic Activity as a Counterion with Ytterbium(III) and Scandium(III)

by Waller, Francis J, Barrett, Anthony G. M, Braddock, D. Christopher, Ramprasad, Dorai, McKinnell, R. Murray, White, Andrew J. P, Williams, David J, Ducray, Richard
Published in Journal of organic chemistry (16.04.1999)

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Abstract B238: Novel imidazo[1,2- a ]pyridines as inhibitors of the IGF-1R tyrosine kinase

Abstract B238: Novel imidazo[1,2- a ]pyridines as inhibitors of the IGF-1R tyrosine kinase

by Ducray, Richard, Simpson, Iain, Jones, Clifford D., Curwen, Jon, Trigwell, Catherine B., Veldman-Jones, Margaret H., Fitzek, Martina, Walker, Graeme E., Ward, Lara T., Hudson, Kevin, Pass, Martin
Published in Molecular cancer therapeutics (12.11.2011)

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