A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction
Rooney, Timothy P. C., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A., Hay, Duncan A., Martin, Sarah, Tumber, Anthony, Rogers, Catherine M., Philpott, Martin, Wang, Minghua, Thompson, Amber L., Heightman, Tom D., Pryde, David C., Cook, Andrew, Paton, Robert S., Müller, Susanne, Knapp, Stefan, Brennan, Paul E., Conway, Stuart J.
Published in Angewandte Chemie International Edition (10.06.2014)
Published in Angewandte Chemie International Edition (10.06.2014)
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Journal Article
Design and Identification of a Novel, Functionally Subtype Selective GABA(A) Positive Allosteric Modulator (PF-06372865)
Owen, Robert M., Blakemore, David, Cao, Lishuan, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R., Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A., Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C., Reynolds, David S., Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S., Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Journal Article
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Tseng, Wei Chou, Pryde, David C., Yoger, Katrina E., Padilla, Karen M., Antonio, Brett M., Han, Seungil, Shanmugasundaram, Veerabahu, Gerlach, Aaron C.
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
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Journal Article
An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes
Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.
Published in Structure (London) (03.04.2018)
Published in Structure (London) (03.04.2018)
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Journal Article
New lithium-zincate approaches for the selective functionalisation of pyrazine: direct dideprotozincation vs. nucleophilic alkylation
Baillie, Sharon E, Blair, Victoria L, Blakemore, David C, Hay, Duncan, Kennedy, Alan R, Pryde, David C, Hevia, Eva
Published in Chemical communications (Cambridge, England) (14.02.2012)
Published in Chemical communications (Cambridge, England) (14.02.2012)
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Journal Article
Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1
Monteillier, Aymeric, Loucif, Alexandre, Omoto, Kiyoyuki, Stevens, Edward B., Lainez, Sergio, Saintot, Pierre-Philippe, Cao, Lishuang, Pryde, David C.
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Corrigendum to “Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1” [Bioorg. Med. Chem. Lett. 26 (2016) 4919–4924]
Monteillier, Aymeric, Loucif, Alexandre, Omoto, Kiyoyuki, Stevens, Edward B., Lainez, Sergio, Saintot, Pierre-Philippe, Cao, Lishuang, Pryde, David C.
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
Published in Bioorganic & medicinal chemistry letters (01.05.2017)
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Journal Article
The design and discovery of novel amide CCR5 antagonists
Pryde, David C., Corless, Martin, Fenwick, David R., Mason, Helen J., Stammen, Blanda C., Stephenson, Peter T., Ellis, David, Bachelor, David, Gordon, David, Barber, Christopher G., Wood, Anthony, Middleton, Donald S., Blakemore, David C., Parsons, Gemma C., Eastwood, Rachel, Platts, Michelle Y., Statham, Keith, Paradowski, Kerry A., Burt, Catherine, Klute, Wolfgang
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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Journal Article
Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain
Andrews, Mark D, af Forselles, Kerry, Beaumont, Kevin, Galan, Sébastien R. G, Glossop, Paul A, Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S, Lunn, Graham, Maw, Graham, Owen, Robert M, Pryde, David C, Roberts, Dannielle, Tran, Thien Duc
Published in ACS medicinal chemistry letters (09.04.2015)
Published in ACS medicinal chemistry letters (09.04.2015)
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Journal Article
Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K 2P 18.1
Monteillier, Aymeric, Loucif, Alexandre, Omoto, Kiyoyuki, Stevens, Edward B, Lainez, Sergio, Saintot, Pierre-Philippe, Cao, Lishuang, Pryde, David C
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
Published in Bioorganic & medicinal chemistry letters (15.10.2016)
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Journal Article
Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads
Oduor, Richard O, Ojo, Kayode K, Williams, Gareth P, Bertelli, Francois, Mills, James, Maes, Louis, Pryde, David C, Parkinson, Tanya, Van Voorhis, Wesley C, Holler, Tod P
Published in PLoS neglected tropical diseases (01.04.2011)
Published in PLoS neglected tropical diseases (01.04.2011)
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Journal Article
Discovery of a Series of Indazole TRPA1 Antagonists
Pryde, David C, Marron, Brian E, West, Christopher W, Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J, Turner, Jamie, Warmus, Joseph S, Swain, Nigel A, Omoto, Kiyoyuki, Mahoney, John H, Gerlach, Aaron C
Published in ACS medicinal chemistry letters (08.06.2017)
Published in ACS medicinal chemistry letters (08.06.2017)
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Journal Article
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism
Pryde, David C., Tran, Thien-Duc, Jones, Peter, Duckworth, Jonathan, Howard, Martin, Gardner, Iain, Hyland, Ruth, Webster, Rob, Wenham, Tracey, Bagal, Sharan, Omoto, Kiyoyuki, Schneider, Richard P., Lin, Jian
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
Published in Bioorganic & medicinal chemistry letters (15.04.2012)
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Journal Article
Analysis of Differential Efficacy and Affinity of GABAA (α1/α2) Selective Modulators
Ain, Qurrat U, Owen, Robert M, Omoto, Kiyoyuki, Torella, Rubben, Bulusu, Krishna C, Pryde, David C, Glen, Robert C, Fuchs, Julian E, Bender, Andreas
Published in Molecular pharmaceutics (07.11.2016)
Published in Molecular pharmaceutics (07.11.2016)
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Journal Article
Analysis of Differential Efficacy and Affinity of GABA A (α1/α2) Selective Modulators
Ain, Qurrat U, Owen, Robert M, Omoto, Kiyoyuki, Torella, Rubben, Bulusu, Krishna C, Pryde, David C, Glen, Robert C, Fuchs, Julian E, Bender, Andreas
Published in Molecular pharmaceutics (07.11.2016)
Published in Molecular pharmaceutics (07.11.2016)
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Journal Article
The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 1
Tran, Thien Duc, Wakenhut, Florian, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Brimage, Rebecca A., Halstead, Rebecca, Glen, Rebecca, Wilson, Craig P., Adam, Fiona, Hay, Duncan, Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C.
Published in ChemMedChem (01.07.2014)
Published in ChemMedChem (01.07.2014)
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Journal Article
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection
Tran, Thien-Duc, Pryde, David C., Jones, Peter, Adam, Fiona M., Benson, Neil, Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Gardner, Iain, Jones, Hannah M., Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Journal Article
The Discovery of Potent Nonstructural Protein 5A (NS5A) Inhibitors with a Unique Resistance Profile-Part 2
Wakenhut, Florian, Tran, Thien Duc, Pickford, Chris, Shaw, Stephen, Westby, Mike, Smith-Burchnell, Caroline, Watson, Lesa, Paradowski, Michael, Milbank, Jared, Stonehouse, David, Cheung, Kathy, Wybrow, Robert, Daverio, Felice, Crook, Samuel, Statham, Keith, Leese, David, Stead, Darren, Adam, Fiona, Hay, Duncan, Roberts, Lee R., Chiva, Jean-Yves, Nichols, Carly, Blakemore, David C., Goetz, Gilles H., Che, Ye, Gardner, Iain, Dayal, Satish, Pike, Andrew, Webster, Rob, Pryde, David C.
Published in ChemMedChem (01.07.2014)
Published in ChemMedChem (01.07.2014)
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Journal Article
Small, non-peptide C5a receptor antagonists: Part 1
Blagg, Julian, Mowbray, Charles, Pryde, David C., Salmon, Gary, Schmid, Esther, Fairman, David, Beaumont, Kevin
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Journal Article
Non-benzimidazole containing inhibitors of respiratory syncytial virus
Pryde, David C., Tran, Thien-Duc, Gardner, Iain, Bright, Helen, Stupple, Paul, Galan, Sebastien, Alsop, Liam, Watson, Lesa, Middleton, Donald S., Dayal, Satish, Platts, Michelle, Murray, Edward J., Parkinson, Tanya, Webster, Robert
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
Published in Bioorganic & medicinal chemistry letters (01.02.2013)
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