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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects
Shen, Hong, Chen, Weiqi, Drexler, Dieter M., Mandlekar, Sandhya, Holenarsipur, Vinay K., Shields, Eric E., Langish, Robert, Sidik, Kurex, Gan, Jinping, Humphreys, W. Griffith, Marathe, Punit, Lai, Yurong
Published in Drug metabolism and disposition (01.08.2017)
Published in Drug metabolism and disposition (01.08.2017)
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Mechanisms and Clinical Significance of Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2017
Yu, Jingjing, Petrie, Ichiko D., Levy, René H., Ragueneau-Majlessi, Isabelle
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Extrapolation of In Vivo Hepatic Clearance from In Vitro Uptake Clearance by Suspended Human Hepatocytes for Anionic Drugs with High Binding to Human Albumin: Improvement of In Vitro-to-In Vivo Extrapolation by Considering the “Albumin-Mediated” Hepatic Uptake Mechanism on the Basis of the “Facilitated-Dissociation Model”
Kim, Soo-Jin, Lee, Kyeong-Ryoon, Miyauchi, Seiji, Sugiyama, Yuichi
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Commensal Gut Bacteria Convert the Immunosuppressant Tacrolimus to Less Potent Metabolites
Guo, Yukuang, Crnkovic, Camila Manoel, Won, Kyoung-Jae, Yang, Xiaotong, Lee, John Richard, Orjala, Jimmy, Lee, Hyunwoo, Jeong, Hyunyoung
Published in Drug metabolism and disposition (01.03.2019)
Published in Drug metabolism and disposition (01.03.2019)
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Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation
Tian, Yuan, Cai, Jingwei, Gui, Wei, Nichols, Robert G., Koo, Imhoi, Zhang, Jingtao, Anitha, Mallappa, Patterson, Andrew D.
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities
Zhang, Donglu, Hop, Cornelis E C A, Patilea-Vrana, Gabriela, Gampa, Gautham, Seneviratne, Herana Kamal, Unadkat, Jashvant D, Kenny, Jane R, Nagapudi, Karthik, Di, Li, Zhou, Lian, Zak, Mark, Wright, Matthew R, Bumpus, Namandjé N, Zang, Richard, Liu, Xingrong, Lai, Yurong, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Risk of Clinically Relevant Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration Between 2013 and 2016
Yu, Jingjing, Zhou, Zhu, Tay-Sontheimer, Jessica, Levy, René H., Ragueneau-Majlessi, Isabelle
Published in Drug metabolism and disposition (01.06.2018)
Published in Drug metabolism and disposition (01.06.2018)
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The Roles of Xenobiotic Receptors: Beyond Chemical Disposition
Mackowiak, Bryan, Hodge, Jessica, Stern, Sydney, Wang, Hongbing
Published in Drug metabolism and disposition (01.09.2018)
Published in Drug metabolism and disposition (01.09.2018)
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A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the “Metabolites in Safety Testing” Regulatory Guidance
Schadt, Simone, Bister, Bojan, Chowdhury, Swapan K., Funk, Christoph, Hop, Cornelis E.C.A., Humphreys, W. Griffith, Igarashi, Fumihiko, James, Alexander D., Kagan, Mark, Khojasteh, S. Cyrus, Nedderman, Angus N.R., Prakash, Chandra, Runge, Frank, Scheible, Holger, Spracklin, Douglas K., Swart, Piet, Tse, Susanna, Yuan, Josh, Obach, R. Scott
Published in Drug metabolism and disposition (01.06.2018)
Published in Drug metabolism and disposition (01.06.2018)
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Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics
Basit, Abdul, Radi, Zaher, Vaidya, Vishal S., Karasu, Matthew, Prasad, Bhagwat
Published in Drug metabolism and disposition (01.08.2019)
Published in Drug metabolism and disposition (01.08.2019)
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Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans
Podoll, Terry, Pearson, Paul G., Evarts, Jerry, Ingallinera, Tim, Bibikova, Elena, Sun, Hao, Gohdes, Mark, Cardinal, Kristen, Sanghvi, Mitesh, Slatter, J. Greg
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
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Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1
Medwid, Samantha, Li, Mandy M.J., Knauer, Michael J., Lin, Kathleen, Mansell, Sara E., Schmerk, Crystal L., Zhu, Catherine, Griffin, Katelyn E., Yousif, Mohamed D., Dresser, George K., Schwarz, Ute I., Kim, Richard B., Tirona, Rommel G.
Published in Drug metabolism and disposition (01.08.2019)
Published in Drug metabolism and disposition (01.08.2019)
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Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation
Yan, Tingting, Wang, Hong, Cao, Lijuan, Wang, Qiong, Takahashi, Shogo, Yagai, Tomoki, Li, Guolin, Krausz, Kristopher W., Wang, Guangji, Gonzalez, Frank J., Hao, Haiping
Published in Drug metabolism and disposition (01.09.2018)
Published in Drug metabolism and disposition (01.09.2018)
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Development of a Novel Maternal-Fetal Physiologically Based Pharmacokinetic Model I: Insights into Factors that Determine Fetal Drug Exposure through Simulations and Sensitivity Analyses
Zhang, Zufei, Imperial, Marjorie Z., Patilea-Vrana, Gabriela I., Wedagedera, Janak, Gaohua, Lu, Unadkat, Jashvant D.
Published in Drug metabolism and disposition (01.08.2017)
Published in Drug metabolism and disposition (01.08.2017)
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