The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors
Spaan, András N., Henry, Thomas, van Rooijen, Willemien J.M., Perret, Magali, Badiou, Cédric, Aerts, Piet C., Kemmink, Johan, de Haas, Carla J.C., van Kessel, Kok P.M., Vandenesch, François, Lina, Gérard, van Strijp, Jos A.G.
Published in Cell host & microbe (15.05.2013)
Published in Cell host & microbe (15.05.2013)
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Polymerization of C9 enhances bacterial cell envelope damage and killing by membrane attack complex pores
Doorduijn, Dennis J, Heesterbeek, Dani A C, Ruyken, Maartje, de Haas, Carla J C, Stapels, Daphne A C, Aerts, Piet C, Rooijakkers, Suzan H M, Bardoel, Bart W
Published in PLoS pathogens (01.11.2021)
Published in PLoS pathogens (01.11.2021)
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Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3)
Koymans, Kirsten J., Feitsma, Louris J., Brondijk, T. Harma C., Aerts, Piet C., Lukkien, Eddie, Lössl, Philip, vanKessel, Kok P. M., de Haas, Carla J. C., van Strijp, Jos A. G., Huizinga, Eric G.
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (01.09.2015)
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Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation
van der Lans, Sjors P. A., Bardoel, Bart W., Ruyken, Maartje, de Haas, Carla J. C., Baijens, Stan, Muts, Remy M., Scheepmaker, Lisette M., Aerts, Piet C., van ’t Wout, Marije F. L., Preiner, Johannes, Marijnissen, Renoud J., Schuurman, Janine, Beurskens, Frank J., Kerkman, Priscilla F., Rooijakkers, Suzan H. M.
Published in Nature communications (16.09.2024)
Published in Nature communications (16.09.2024)
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Monoclonal antibodies effectively potentiate complement activation and phagocytosis of Staphylococcus epidermidis in neonatal human plasma
de Vor, Lisanne, Beudeker, Coco R, Flier, Anne, Scheepmaker, Lisette M, Aerts, Piet C, Vijlbrief, Daniel C, Bekker, Mireille N, Beurskens, Frank J, van Kessel, Kok P M, de Haas, Carla J C, Rooijakkers, Suzan H M, van der Flier, Michiel
Published in Frontiers in immunology (29.07.2022)
Published in Frontiers in immunology (29.07.2022)
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Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing
Muts, Remy M., den Boer, Maurits A., Bardoel, Bart W., Aerts, Piet C., de Haas, Carla J. C., Heck, Albert J. R., Rooijakkers, Suzan H. M., Heesterbeek, Dani A. C.
Published in Scientific reports (01.11.2023)
Published in Scientific reports (01.11.2023)
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Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models
Zwarthoff, Seline A, Berends, Evelien T M, Mol, Sanne, Ruyken, Maartje, Aerts, Piet C, Józsi, Mihály, de Haas, Carla J C, Rooijakkers, Suzan H M, Gorham, Jr, Ronald D
Published in Frontiers in immunology (23.07.2018)
Published in Frontiers in immunology (23.07.2018)
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Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae
Aguinagalde Salazar, Leire, den Boer, Maurits A, Castenmiller, Suzanne M, Zwarthoff, Seline A, de Haas, Carla, Aerts, Piet C, Beurskens, Frank J, Schuurman, Janine, Heck, Albert J R, van Kessel, Kok, Rooijakkers, Suzan H M
Published in eLife (22.03.2023)
Published in eLife (22.03.2023)
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Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm
de Vor, Lisanne, van Dijk, Bruce, van Kessel, Kok, Kavanaugh, Jeffrey S, de Haas, Carla, Aerts, Piet C, Viveen, Marco C, Boel, Edwin C, Fluit, Ad C, Kwiecinski, Jakub M, Krijger, Gerard C, Ramakers, Ruud M, Beekman, Freek J, Dadachova, Ekaterina, Lam, Marnix Geh, Vogely, H Charles, van der Wal, Bart Ch, van Strijp, Jos Ag, Horswill, Alexander R, Weinans, Harrie, Rooijakkers, Suzan Hm
Published in eLife (06.01.2022)
Published in eLife (06.01.2022)
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Glycan-specific IgM is critical for human immunity to Staphylococcus aureus
Hendriks, Astrid, Kerkman, Priscilla F., Varkila, Meri R.J., Haitsma Mulier, Jelle L.G., Ali, Sara, ten Doesschate, Thijs, van der Vaart, Thomas W., de Haas, Carla J.C., Aerts, Piet C., Cremer, Olaf L., Bonten, Marc J.M., Nizet, Victor, Liu, George Y., Codée, Jeroen D.C., Rooijakkers, Suzan H.M., van Strijp, Jos A.G., van Sorge, Nina M.
Published in Cell reports. Medicine (17.09.2024)
Published in Cell reports. Medicine (17.09.2024)
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Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes
Berends, Evelien T M, Gorham, Jr, Ronald D, Ruyken, Maartje, Soppe, Jasper A, Orhan, Hatice, Aerts, Piet C, de Haas, Carla J C, Gros, Piet, Rooijakkers, Suzan H M
Published in BMC biology (09.11.2015)
Published in BMC biology (09.11.2015)
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Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation
Cruz, Ana Rita, den Boer, Maurits A., Strasser, Jürgen, Zwarthoff, Seline A., Beurskens, Frank J., de Haas, Carla J. C., Aerts, Piet C., Wang, Guanbo, de Jong, Rob N., Bagnoli, Fabio, van Strijp, Jos A. G., van Kessel, Kok P. M., Schuurman, Janine, Preiner, Johannes, Heck, Albert J. R., Rooijakkers, Suzan H. M.
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (16.02.2021)
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C1q binding to surface-bound IgG is stabilized by C1r₂s₂ proteases
Zwarthoff, Seline A., Widmer, Kevin, Kuipers, Annemarie, Strasser, Jürgen, Ruyken, Maartje, Aerts, Piet C., de Haas, Carla J. C., Ugurlar, Deniz, den Boer, Maurits A., Vidarsson, Gestur, van Strijp, Jos A. G., Gros, Piet, Parren, Paul W. H. I., van Kessel, Kok P. M., Preiner, Johannes, Beurskens, Frank J., Schuurman, Janine, Ricklin, Daniel, Rooijakkers, Suzan H. M.
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2021)
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Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains
de Jong, Nienke W.M., Vrieling, Manouk, Garcia, Brandon L., Koop, Gerrit, Brettmann, Matt, Aerts, Piet C., Ruyken, Maartje, van Strijp, Jos A.G., Holmes, Mark, Harrison, Ewan M., Geisbrecht, Brian V., Rooijakkers, Suzan H.M.
Published in The Journal of biological chemistry (23.03.2018)
Published in The Journal of biological chemistry (23.03.2018)
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Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia
Kerkman, Priscilla F, de Vor, Lisanne, van der Vaart, Thomas W, Ten Doesschate, Thijs, Muts, Remy M, Depelteau, Jamie S, Scheepmaker, Lisette M, Ruyken, Maartje, de Haas, Carla J C, Aerts, Piet C, Marijnissen, Renoud J, Schuurman, Janine, Beurskens, Frank J, Gorlani, Andrea, Bardoel, Bart W, Rooijakkers, Suzan H M
Published in The Journal of immunology (1950) (25.10.2024)
Published in The Journal of immunology (1950) (25.10.2024)
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The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils
Zhao, Yuxi, van Woudenbergh, Esther, Zhu, Jing, Heck, Albert J R, van Kessel, Kok P M, de Haas, Carla J C, Aerts, Piet C, van Strijp, Jos A G, McCarthy, Alex J
Published in The Journal of immunology (1950) (15.02.2020)
Published in The Journal of immunology (1950) (15.02.2020)
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Photoimmuno-antimicrobial therapy for Staphylococcus aureus implant infection
Dijk, Bruce van, Oliveira, Sabrina, Hooning van Duyvenbode, J Fred F, Nurmohamed, F Ruben H A, Mashayekhi, Vida, Hernández, Irati Beltrán, van Strijp, Jos, de Vor, Lisanne, Aerts, Piet C, Vogely, H Charles, Weinans, Harrie, van der Wal, Bart C H
Published in PloS one (08.03.2024)
Published in PloS one (08.03.2024)
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