Characterization of Alisertib (MLN8237), an Investigational Small-Molecule Inhibitor of Aurora A Kinase Using Novel In Vivo Pharmacodynamic Assays
MANFREDI, Mark G, ECSEDY, Jeffrey A, WYSONG, Deborah R, JANOWICK, David A, HYER, Marc L, LEROY, Patrick J, GERSHMAN, Rachel E, SILVA, Matthew D, GERMANOS, Melissa S, BOLEN, Joseph B, CLAIBORNE, Christopher F, SELLS, Todd B, CHAKRAVARTY, Arijit, SILVERMAN, Lee, MENGKUN ZHANG, HOAR, Kara M, STROUD, Stephen G, WEI CHEN, SHINDE, Vaishali, HUCK, Jessica J
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Published in Clinical cancer research (15.12.2011)
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Emergetic and cosmic exergy-based ecological assessments of long-term raised field eco-farming systems in saline–alkaline lands
Hu, Hengyu, Zhang, Mengkun, Zhang, Yin, Fu, Min, Chen, Jiansheng, Li, Geng, Zhai, Mingzhen, Ming, Xiuyun, Ning, Tangyuan
Published in Ecological indicators (01.06.2021)
Published in Ecological indicators (01.06.2021)
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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
Manfredi, Mark G, Ecsedy, Jeffrey A, Meetze, Kristan A, Balani, Suresh K, Burenkova, Olga, Chen, Wei, Galvin, Katherine M, Hoar, Kara M, Huck, Jessica J, LeRoy, Patrick J, Ray, Emily T, Sells, Todd B, Stringer, Bradley, Stroud, Stephen G, Vos, Tricia J, Weatherhead, Gabriel S, Wysong, Deborah R, Zhang, Mengkun, Bolen, Joseph B, Claiborne, Christopher F
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (06.03.2007)
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Responses of soil nutrients, enzyme activities, and maize yield to straw and plastic film mulching in coastal saline-alkaline
Liu, Zhen, Zhang, Mengkun, Wang, Zengjiao, Shen, Ying, Zhang, Deheng, Zhang, Shenghao, Qi, Xingchao, Zhang, Xuepeng, Sun, Tao, Tian, Shenzhong, Ning, Tangyuan
Published in Plant, soil and environment (01.01.2024)
Published in Plant, soil and environment (01.01.2024)
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Targeting Aurora A kinase activity with the investigational agent alisertib increases the efficacy of cytarabine through a FOXO-dependent mechanism
Kelly, Kevin R., Nawrocki, Steffan T., Espitia, Claudia M., Zhang, Mengkun, Yang, Johnny J., Padmanabhan, Swaminathan, Ecsedy, Jeffrey, Giles, Francis J., Carew, Jennifer S.
Published in International journal of cancer (01.12.2012)
Published in International journal of cancer (01.12.2012)
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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
Sells, Todd B., Chau, Ryan, Ecsedy, Jeffrey A., Gershman, Rachel E., Hoar, Kara, Huck, Jessica, Janowick, David A., Kadambi, Vivek J., LeRoy, Patrick J., Stirling, Matthew, Stroud, Stephen G., Vos, Tricia J., Weatherhead, Gabriel S., Wysong, Deborah R., Zhang, Mengkun, Balani, Suresh K., Bolen, Joseph B., Manfredi, Mark G., Claiborne, Christopher F.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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Preclinical pharmacokinetic/pharmacodynamic/efficacy relationships for alisertib, an investigational small-molecule inhibitor of Aurora A kinase
Palani, Santhosh, Patel, Mayankbhai, Huck, Jessica, Zhang, Mengkun, Balani, Suresh K., Yang, Johnny, Chen, Susan, Mettetal, Jerome, Manfredi, Mark, Shyu, Wen Chyi, Ecsedy, Jeffrey A., Chakravarty, Arijit
Published in Cancer chemotherapy and pharmacology (01.12.2013)
Published in Cancer chemotherapy and pharmacology (01.12.2013)
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Water sources effects on soil salinity and biomass production of agriculture and agroforest systems in raised fields
Hu, Hengyu, Zhang, Mengkun, Fu, Min, Qin, Jihao, Chen, Jiansheng, Feng, Yupeng, Li, Geng, Zhai, Mingzhen, Zhang, Yin, Ning, Tangyuan
Published in Journal of plant interactions (01.01.2020)
Published in Journal of plant interactions (01.01.2020)
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Phase I Assessment of New Mechanism-Based Pharmacodynamic Biomarkers for MLN8054, a Small-Molecule Inhibitor of Aurora A Kinase
CHAKRAVARTY, Arijit, SHINDE, Vaishali, ANDREU, Jordi, RODRIGUEZ-BRAUN, Edith, ROSELLO, Susana, VON MEHREN, Margaret, MEROPOL, Neal J, LANGER, Corey J, ONEIL, Bert, BOWMAN, Douglas, MENGKUN ZHANG, DANAEE, Hadi, TABERNERO, Josep, FARON-YOWE, Laura, GRAY, Gary, HUA LIU, PAPPAS, Jodi, SILVERMAN, Lee, SIMPSON, Chris, STRINGER, Bradley, TIRRELL, Stephen, VEIBY, Ole Petter, VENKATAKRISHNAN, Karthik, CERVANTES, Andres, GALVIN, Katherine, MANFREDI, Mark, ECSEDY, Jeffrey A, COHEN, Roger B, DEES, E. Claire, BURRIS, Howard, INFANTE, Jeffrey R, MACARUILA, Teresa, ELEZ, Elena
Published in Cancer research (Chicago, Ill.) (01.02.2011)
Published in Cancer research (Chicago, Ill.) (01.02.2011)
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Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma
Cen, Osman, Kannan, Karuppiah, Huck Sappal, Jessica, Yu, Jie, Zhang, Mengkun, Arikan, Muzaffer, Ucur, Ali, Ustek, Duran, Cen, Yeter, Gordon, Leo, Longnecker, Richard
Published in mSphere (22.08.2018)
Published in mSphere (22.08.2018)
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Immediate and long-term effects of tillage practices with crop residue on soil water and organic carbon storage changes under a wheat-maize cropping system
Zhao, Hongxiang, Qin, Jihao, Gao, Tianping, Zhang, Mengkun, Sun, Hongchang, Zhu, Shuwei, Xu, Cailong, Ning, Tangyuan
Published in Soil & tillage research (01.04.2022)
Published in Soil & tillage research (01.04.2022)
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Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: Co-stimulation of AP-1 and CRE nuclear binding proteins
Miller, Caroline, Zhang, Mengkun, He, Yulan, Zhao, Jie, Pelletier, Jean-Pierre, Martel-Pelletier, Johanne, Di Battista, John A.
Published in Journal of cellular biochemistry (15.06.1998)
Published in Journal of cellular biochemistry (15.06.1998)
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A novel fluorapatite-type deep-red CsSr3La(PO4)3F:Eu3+ phosphor with intense 5D0-7F4 transition for temperature sensors, plant growth lighting, and w-LEDs
Li, Jiayi, Chen, Xingyu, Gao, Di, Zhang, Mengxue, Zhang, Mengkun, Wang, Siyan, Liu, Xiang, Yu, Ruijin
Published in Journal of luminescence (01.11.2024)
Published in Journal of luminescence (01.11.2024)
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Thermal stable NaMgLaTeO6:Dy3+ double perovskite yellow phosphors for w-LEDs and latent fingerprint visualization
Xie, Xinjing, Tuo, Yangyang, Cheng, Siyu, Gao, Di, Zhang, Mengkun, Liu, Xiang, Deng, Huajuan, Yu, Ruijin
Published in Materials research bulletin (01.01.2025)
Published in Materials research bulletin (01.01.2025)
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Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation
HOMEISTER, J. W, MENGKUN ZHANG, FRENETTE, P. S, HYNES, R. O, WAGNER, D. D, LOWE, J. B, MARKS, R. M
Published in Blood (01.10.1998)
Published in Blood (01.10.1998)
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TAK-659 in combination with NKTR-214 and anti-PD-1 therapy leads to complete and sustained tumor regression and immune memory in pre-clinical syngeneic models
Yu, Jie, Sappal, Jessica Huck, Zhang, Mengkun, Kannan, Karuppiah, Zalevsky, Jonathan
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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Abstract 3844: TAK-659, a SYK kinase inhibitor, demonstrates preclinical antitumor activity in solid tumor models
Sappal, Jessica J., Theisen, Matthew, Xiang, Zhongmin, Tirrell, Stephen, Christmas, Rudy, Yu, Jie, Zhang, Mengkun, Kannan, Karuppiah
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Anti-tumor activity of TAK-659, a dual inhibitor of SYK and FLT-3 kinases, in AML models
Yu, Jie, Huck, Jessica, Theisen, Matthew, He, Helen, Tirrell, Stephen, Zhang, Mengkun, Kannan, Karuppiah
Published in Journal of clinical oncology (20.05.2016)
Published in Journal of clinical oncology (20.05.2016)
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Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models
Koenig, Erik M., Li, Cong, Yang, Huyuan, Zhu, Andy, Shah, Pooja, Nishimura, Kazuho, Bannerman, Bret, zhang, Mengkun, Stringer, Bradley, Bahamon, Brittany, Veiby, O. Petter, Abu-Yousif, Adnan
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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